From the foregoing the writer draws the following conclusions:

1. The use of splenic extract in the diet of patients suffering with bone and joint tuberculosis has been found very beneficial, as improvement is noted in the febrile condition, the local reactions, the growth, the weight, the color, the appetite, the blood composition, the deformity, the complications, the roentgen picture, the activity permissible to the patients, and the dispensing with support.

2. Improvement from splenic extract treatment probably will be more apparent to those who are unable to enforce a strict compliance with the accepted ideal treatment,—i.e., support, recumbency, heliotherapy, proper feeding, and proper aeration.

3. The production of splenic extract is possible and the distribution is practicable.

4. It is possible to obtain the cooperation of patients in adopting the splenic extract diet, even of those in remote sections.

5. Splenic extract treatment has also produced improvement in osteomyelitis (acute and chronic) and in ununited fractures. This investigation is well under way.

6. Enough improvement has been shown in the blood composition to stimulate further study of this phase.

7. The writer cannot explain the improvement gained by the administration of splenic extract. Various explanations given so far may all be true, but these investigations lead to the belief that as yet there is no certainty as to which is the most important factor.