1. In cases of chronic osteomyelitis every effort should be made to cause draining sinuses to heal.
2. If malignancy is suspected from the appearance of a mass, foul odor, pain, or hemorrhage, biopsy should be performed at once. If malignancy is found, amputation should be done immediately.
3. It is advisable to follow the amputation by treatment with deep roentgen rays or radium.