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THE EFFECT OF LARGE DOSES OF X-RAYS ON THE GROWTH OF YOUNG BONE
EUGENE M. REGEN; WALTER E. WILKINS
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The Department of Surgery, Vanderbilt University School of Medicine, Nashville The Department of Biochemistry, Vanderbilt University School of Medicine, Nashville
1935 by The Journal of Bone and Joint Surgery.
The Journal of Bone & Joint Surgery.  1936; 18:61-68 
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Abstract

Eight of a group of fourteen pure-bred young rabbits of the same age were treated over the left forelegs with 2,600 roentgens; the remaining six animals were used as controls. Roentgenograms of both forelegs of each animal were made at monthly intervals until growth in the controls had ceased. Growth in the radii and ulnae was followed by careful measurement of the roentgenograms for a period of eight months, giving a total of 369 observations. Sometime within the first month, growth in the treated bones stopped completely and did not reappear during the period of observation. Growth in the untreated bones of the experimental animals was not affected.

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    Accreditation Statement
    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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