This paper is based on a series of forty cases of benign giant-cell tumor of bone, in which excision of the tumor and bone grafting were employed. The history, as well as the clinical, roentgenographic, and microscopic findings, and the follow-up data have been reviewed in all forty cases, and the diagnosis of benign giant-cell tumor has been confirmed. Massive resection and excision by curettage and cauterization appear to be safe methods of eradicating the tumor. The resultant cavities have been filled with autogenous bone, which stimulates rapid formation of bone, lessens the danger of collapse from fracture, and tends to prevent deformity and disability. Excision of the tumor and bone grafting is a safe procedure in properly selected cases, and it tends to prevent deformity and disability.