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HOMOLOGOUS-SERUM HEPATITIS FOLLOWING THE USE OF REFRIGERATED BONE-BANK BONE Report of a Case
Ned M. Shutkin
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Division of Orthopaedic Surgery, Department of Surgery, Yale University School of Medicine, New Haven
1954 by The Journal of Bone and Joint Surgery, Incorporated
The Journal of Bone & Joint Surgery.  1954; 36:160-162 
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Abstract

1. Homologous-serum hepatitis is a form of human hepatitis produced by the parenteral inoculation of human blood or its products containing the appropriate virus.

2. It has been estimated that as little as 1 per cent. of one cubic centimeter of contaminated blood is sufficient to introduce the disease into the recipient. Simple acupuncture has been known to transmit the disease through a contaminated needle.

3. It is reasonable to assume that the usual amount of bone used in any bone-grafting procedure will contain more than the minimum of blood required for transmission.

4. It has been shown that the properties of the offending virus allow it to survive the usual storage methods of refrigeration or immersion in merthiolate for a time well beyond that during which bank bone is routinely stored.

5. The same precautions as in selecting blood donors should be exercised in selecting bone donors.

6. Surgeons who utilize stored bone should be conversant with any newly discovered method whereby the presence of the hepatitis virus can be determined in a prospective donor of either blood or bone in any easy and practical way.

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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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