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In Vivo Osteocyte Death
Harold M. Frost
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Detroit, Michigan
1960 by The Journal of Bone and Joint Surgery, Incorporated
The Journal of Bone & Joint Surgery.  1960; 42:138-143 
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Abstract

Counts of the percentage of empty osteocyte lacunae were done on fresh, undecalcified bone sections of specimens from forty-five human subjects ranging in age from new-born infancy to eighty-four years. The average figures from arbitrary age groups suggest that an increasing percentage of bone dies with increasing age. At seventy years, 45 per cent of Haversian bone and 75 per cent of extra-Haversian bone have empty lacunae.

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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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