In rats periosteal proliferations of autogenous and homogenous transplants
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are vascularized within forty-eight hours after transplantation. Until the eighth day after transplantation there is no detectable difference between autogenous and homogenous-bone transplants. In the ensuing seventy-two hours the autogenous transplant continues to proliferate but the homogenous transplant evokes an inflammatory response that obliterates the vascular supply to its periosteal proliferations. The periosteal proliferations from the homogenous transplants undergo necrosis by the tenth day after transplantation.
Determination of the interval following transplantation at which the original vascular ingrowth to homogenous-bone transplants is obliterated may be a method of quantitatively evaluating the intensity of the inflammatory response to various types of transplants.