Ewing's sarcoma is an entity among the malignant neoplasms of bone. Death can result from this tumor after many years, although the lesion usually produces death within two years after diagnosis. Despite the usually lethal effect of Ewing's sarcoma, nearly 10 per cent of patients affected can be cured. Our data indicate that irradiation, ablative surgical treatment, or combinations of these can be curative. In the case of tumors of the extremities, amputation with or without preoperative irradiation appears to be the treatment of choice, but the evidence is not overwhelming. Patients who have metastatic processes sometimes can be cured by appropriate irradiation or surgical therapy.