A review of the literature has disclosed three previously reported cases of rhabdomyosarcoma arising within the skeletal muscle of the hand. Nine new cases are added to this group. Rhabdomyosarcoma of the hand is a distinct clinical entity. It is often a painless condition and is brought to medical attention only when it interferes with function or the tumor becomes too large to ignore. No suggestions for treatment are made since the series is too small to be considered authoritative. However, in those patients with complete follow-up, it has been a uniformly fatal disease regardless of treatment.