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Characteristics of Trace Ions Released from Embedded Metal Implants in the Rabbit
Albert B. FergusonJR.; Yoshihiko Akahoshi; Patrick G. Laing; Edwin S. Hodge
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Orthopaedic Department, University of Pittsburgh, and the Mellon Institute, Pittsburgh
1962 by The Journal of Bone and Joint Surgery, Incorporated
The Journal of Bone & Joint Surgery.  1962; 44:323-336 
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Abstract

Vitallium, 316 stainless steel, incoloy, A-286 stainless steel, aluminum 2024-T3, titanium, zirconium, and puromi were embedded in the skeletal muscles of albino rabbits—one alloy to any one animal. Spectrographic analyses of the trace-metal concentration of the surrounding muscle, spleen, lung, liver, kidney, and control muscle were done.

The spleen was found to be the most active site of trace-ion storage, the other organs tending to get rid of an early increase in concentration. Cobalt and nickel were the most active ions in terms of their presence in these organs.

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    Accreditation Statement
    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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