A case is reported of histoplasmosis in which focal involvement of the synovial membrane of the wrist and the os triquetrum dominated the clinical picture. One other case of bone and synovial infection was found. Histoplasmosis should be considered in the differential diagnosis of focal bone and joint lesions occurring in the age groups when primary infection and endogenous reinfection with this organism occur. Excisional surgery can be utilized in these rare cases under the protection of amphotericin B.