Lymphangioma of bone is a disease of unknown etiology in which lytic lesions may be seen in the skull, spine, long bones, pelvis, or ribs. Our case demonstrated multiple lesions in the long bones with decrease in size of the defects over an eighteen month period. The condition is usually discovered during childhood or adolescence, either accidentally or because of a pathological fracture. The diagnosis was made in the present patient at age of three months following a fracture of the femur. Differential diagnosis should include metastatic carcinoma, reticuloendothelial disease, polyostotic fibrous dysplasia, multiple hemangiomatosis, and congenital generalized fibromatosis.