JBJS | Toxicity of Metal Particles in Tissue Culture Part I: A New Assay Method Using Cell Counts in The Phase of Replication

The Journal of Bone & Joint Surgery, Volume 50, Issue 3

Journal Contents | April 01, 1968

Toxicity of Metal Particles in Tissue Culture Part I: A New Assay Method Using Cell Counts in The Phase of Replication

ARTHUR M. PAPPS; JONATHAN COHEN

Divisions of Orthopedic Surgery and of Laboratories and Research, Children's Hospital Medical Center and Harvard Medical School, Boston

1968 by The Journal of Bone and Joint Surgery, Incorporated

The Journal of Bone & Joint Surgery. 1968; 50:535-547

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Abstract

The toxicity of several corrosion resistant alloys (stainless steel and cobalt chromium) was assayed by exposing tissue cultures to powders of these alloys and counting the cell populations after standard replication intervals. Differences in the degrees of toxicity of these alloys, not demonstrated by in vivo methods, were elicited.

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These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.

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ARTHUR M. PAPPS, JONATHAN COHEN; Toxicity of Metal Particles in Tissue Culture Part I: A New Assay Method Using Cell Counts in The Phase of Replication. The Journal of Bone & Joint Surgery. 1968 Apr;50(3):535-547.

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