1. Nine unrelated kindreds with onycho-osteodysplasia are presented from a small population source suggesting relative frequency of this syndrome.
2. The presence of albuminuria in 39 per cent of affected persons tested supports the inclusion of renal dysplasia as a component of the syndrome. The nature of this dysplasia needs further definition.
3. Mild reduction of stature is demonstrated to be a component of the syndrome.
4. The finding of foot deformity in 46 per cent of affected persons examined suggests that this is also a component of the inherited syndrome. Calcaneovalgus deformity of the hind part of the foot with supination of the fore part of the foot was found to be the predominant deformity.