In the article Intra-articular Thio-tepa Compared with Depo-medrol and Procaine in the Treatment of Arthritis by Anthony G. Gristina, Nicholas A. Pace, Thomas G. Kantor, and Walter A. L. Thompson, in the December 1970 issue, pages 1606 and 1607, the original charts rather than the revised charts were used. It is suggested that the reader paste this page into his December 1970 issue between pages 1606 and 1607.

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the one and three-month evaluation were actually one or two weeks longer than scheduled.

Clinical Results

The degree and duration of pain on motion in the joint injected were essentially

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the same for patients treated by any of the three drugs (Fig. 1).

The measurements of joint circumference indicated a statistically significant superiority of Thio-tepa only over procaine and only in the first week (P < 0.05) (Fig. 2). This calculation was done by the chi-square method performed in pairs, with Yates correction. There is no such difference noted between Thio-tepa and Depo-medrol (P > 0.2) nor was there a significant difference between procaine and Depo-medrol (P > 0.5). One patient in the group injected with Depo-medrol did not have joint circumference measured when he was seen at twelve-weeks.

Active flexion measurements indicated a superiority of the Thio-tepa over the other drugs throughout the period of observations, but the differences are not statistically significant (Fig. 3). Active extensions measurements indicated statistical superiority for Thio-tepa for the one-week observation point when compared with procaine (P < 0.01) but not when compared with Depo-medrol (P > 0.05) (Fig. 4). The other parameters measured, such as warmth of the skin over the joint, degree of