Twenty-eight cases of glomus tumor of the hand have been studied from various aspects including a review of the pertinent literature, clinical manifestations, treatment, and the incidence of this lesion in relation to other hand tumors and to glomus tumors occurring extramanually. These interesting and unusual lesions often are not palpable, frequently not visible, and usually not detectable on roentgen examination. Nonetheless, the diagnosis can be readily made if there is awareness of the characteristic triad of symptoms: pain, tenderness, and cold sensitivity. Meticulous complete excision, the only recommended treatment, should result in complete cure.