JBJS | Heparin Osteoporosis AN EXPERIMENTAL MODEL USING RATS

The Journal of Bone & Joint Surgery, Volume 55, Issue 3

Journal Contents | April 01, 1973

Heparin Osteoporosis AN EXPERIMENTAL MODEL USING RATS

ROBY C. THOMPSONJR.

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From the Department of Orthopaedics, University of Virginia Medical Center, Charlottesville

1973 by The Journal of Bone and Joint Surgery, Incorporated

The Journal of Bone & Joint Surgery. 1973; 55:606-612

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Abstract

Rats injected subcutaneously with heparin daily for eight weeks (clotting time about twice normal for twelve hours daily) showed a decrease in breaking strength of the humerus of about 8 per cent, a decrease in the cross-sectional area of the humeral cortex of about 12.5 per cent and a decrease in the amount of bone collagen synthesis of about 20 per cent as compared with the controls.

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These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.

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ROBY C. THOMPSONJR.; Heparin Osteoporosis AN EXPERIMENTAL MODEL USING RATS. The Journal of Bone & Joint Surgery. 1973 Apr;55(3):606-612.

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