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Fluoride-Induced Changes in Ashed Bone Mineral of Growing Sheep AN X-RAY DIFFRACTION ANALYSIS
PETER JOKL; H. CATHERINE W. SKINNER
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From the Section of Orthopaedic Surgery and the Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven
1973 by The Journal of Bone and Joint Surgery, Incorporated
The Journal of Bone & Joint Surgery.  1973; 55:761-770 
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Abstract

Physical differences were noted in the inner and outer parts of the tibial cortex of a sheep drinking water containing 100 parts per million of fluoride. In this animal's cortex and in the cortex of sheep fed one and ten parts per million, the fluoride content of the mineral was higher than that of a control sheep and higher in the outer than in the inner part of the cortex of the animals receiving fluoride. X-ray diffraction of the mineral phase after ashing demonstrated apatite in all animals and in those receiving ten and 100 parts per million, a second mineral phase, whitlockite, located in the outer cortical bone.

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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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