In fifty-three dogs microcrystalline collagen, thrombin-soaked gelatin
foam, and thrombin powder were evaluated as hemostatic agents when applied
to bleeding cancellous surfaces after osteotomy of the greater trochanter
using two quantitative models: one, a single osteotomy; the other, a double
osteotomy. All three agents significantly reduced bleeding compared with
the controls, the microcrystalline collagen being most effective. At three
months there was no evidence that microcrystalline collagen and
thrombin-gelatin interfered with bone healing after the greater trochanter
was reattached with two wires.