From 1960 through 1975, 337 patients with surgically treated acute
fracture of the hip received subcutaneously administered heparin to prevent
thromboembolic disease according to various regimens. Four hundred and
three patients received no heparin. The incidence of fatal pulmonary
embolism was 3.5 per cent in the 403 patients who reveived no heparin and
0.0 per cent in the 147 patients who were treated by the currently used
regimen of prophylaxis, as follows: With the dose modified according to the
coagulometer-test time, patients received 2,500 units on admission and
every six hours until the day before operation. Then they were given 5,000
to 10,000 units eight to ten hours before surgery and 2,500 units every six
hours after surgery until they were fully mobilized.