We reviewed the published reports of skeletal cryptococcosis and added
three cases to the fifty-six in the literature. Eight of the patients in
the reported cases probably did not have primary skeletal cryptococcosis.
The potential toxicity of antifungal drugs in current use and the apparent
effectiveness of surgical treatment for patients who only have a single
focus of infection in bone, without involvement of other tissues, should be
noted. The association of cryptococcosis with other diseases and the
difficulty in differentiating purely skeletal involvement from more
extensive disease are emphasized.