In twenty-four cases of juxtacortical osteogenic sarcoma, three
histological grades of malignancy were identified and correlated with the
prognosis. The eighteen patients with Grade-I or II tumors had a
significantly better prognosis than the six with Grade-III lesions. The
three grades could not be distinguished roentgenographically. Grade I and
II tumors, which showed a high cure rate after amputation, may be amenable
to en block resection, provided the entire tumor can be removed with a good
margin of uninvolved soft tissue and underlying bone. Grade-III tumors, on
the other hand, had a poor prognosis despite early radical surgery.