A human model system was used to investigate the effect of increased
tissue pressure on different parameters of the function of the nerves and
muscles in the anterior compartment of the leg. Abnormalities of sensation,
strength, motor nerve-conduction velocity, and compound
muscle-action-potential amplitude occurred in a parallel fashion when the
intracompartmental pressure exceeded a threshold value. This threshold was
significantly lowered by elevation of the extremity. Grossly abnormal
functional parameters were consistently elicited when the peripheral pulse
remained intact. The motor nerve-conduction velocity and compound
muscle-action-potential amplitude appear to be reliable, non-invasive, and
quantitative parameters of the physiological status of the neuromuscular
tissue within the compartment.