Ten patients with isolated subcutaneous nodules histologically similar
to rheumatoid nodules were studied. Because of the intense fibroblastic
reaction in one such nodule, it was initially mistaken for a fibrosarcoma.
The nodules tended to be multiple and recurrent, with eventual spontaneous
regression, and they were not associated with any systemic illness. The
etiology of these lesions is unclear but the possibility of subsequent
development of systemic rheumatoid disease is remote.