Electrically generated silver ions have been shown previously to be a
potent antibacterial agent with an exceptionally broad spectrum as
indicated by in vitro testing. The present study reports on clinical
experience using electrically generated silver ions as adjunctive treatment
in the management of chronic osteomyelitis. Fourteen patients had fifteen
treatment attempts: thirteen for chronic osteomyelitis of the tibia, one
for acute and chronic pyarthrosis and osteomyelitis of the knee, and one
for a chronically draining sinus after total hip replacement. Wound
debridement, silver ion iontophoresis, and subsequent wound care (usually
provided by the patient) resulted in control of the infection in twelve of
the fifteen treatment attempts and in healing of the non-union after
follow-up ranging from three to thirty-six months. The other three attempts
led to two partial and one complete failure.