We retrospectively reviewed the cases of eight patients with histiocytic
lymphoma (reticulum-cell sarcoma) appearing as a primary bone lesion.
Histological findings were classified according to the criteria of
Rappaport. Lesions were staged as suggested by the Ann Arbor Conference.
After thorough staging, four of the eight patients were shown to have more
extensive disease than was initially thought, which altered the therapeutic
approach used. Thorough staging is necessary for improved survival of
patients with histiocytic lymphoma of bone. We suggest a diagnostic
strategy for patients with histiocytic lymphoma presenting in bone that
leads to appropriate therapy.