Patients with Ewing's sarcoma of a long bone who survive for two years
from the time of diagnosis and have been treated with irradiation and
chemotherapy have a significant risk of fracture of the involved segment of
bone. In our experience, this risk is especially high when the humerus or
femur is involved. Healing of these fractures is not normal, and our data
suggest that early or even prophylactic internal fixation and bone-grafting
may be indicated.