We studied the proximal tibial physes of mice, seven, fifteen, twenty-two, and twenty-eight days old, to define in mathematical terms the changes in cell profile and profile orientation among growth-plate zones and to determine if cell profile and profile orientation change with changes in the rate of growth. Using electron microscopy, we identified five growth-plate zones: the reserve zone, the upper proliferative zone, the lower proliferative zone, the upper hypertrophic zone, and the lower hypertrophic zone. In transverse sections, cell profiles did not change among growth-plate zones and the degree of cell-profile orientation approached zero in all zones. In longitudinal sections, cell profiles and profile orientations differed significantly among zones. Cell profiles in the upper and lower proliferative zones were eccentric and highly oriented. They became more rounded and the degree of cell orientation decreased between the proliferative and hypertrophic zones. As the rate of longitudinal bone growth decreased, cell profiles and cell-profile orientation changed. The cell profiles in the reserve zone became flatter and in the other zones the cell profiles became more rounded. The degree of cell-profile orientation decreased quadratically in the upper and lower proliferative zones, decreased linearly in the reserve and upper hypertrophic zones, and remained unchanged in the lower hypertrophic zone.