Seven patients who had a low-grade chondrosarcoma of the proximal part
of the humerus or femur were treated by resection, autoclaving of the
excised segment, and reinsertion of that segment with supplementary fresh
autogenous grafts. The length of follow-up ranged from fourteen to
twenty-four years, and sequential roentgenograms were made during the
follow-up period. A biopsy of the autoclaved segments was done in one
patient eleven years after the operation, and examination of the specimen
showed predominantly live bone; there were very few spicules of dead bone.
Although the principal roentgenographic changes were demonstrated by the
end of the first year, serial roentgenograms showed a continuing process of
remodeling for two decades. No secondary procedures were required for
treatment of fracture, resorption, infection, or loss of function.