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Intra-Articular Penetration of the Knee Joint by a Fragment of Cortical Bone during Intramedullary Nailing of the Femur. A Report of Two Cases*
DARREN L. JOHNSON, M.D.†; DONALD A. WISS, M.D.‡, LOS ANGELES, CALIFORNIA
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Investigation performed at the Division of Hand Surgery, Department of Orthopaedic Surgery, University of California, Davis Medical Center, Sacramento
The Journal of Bone & Joint Surgery.  1996; 78:1092-5 
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The preferred treatment for comminuted fractures of the femur extending from the lesser trochanter to the adductor tubercle is fixation with an intramedullary locking nail5-7,11,12,15,24-31. The reported intraoperative complications of nailing have included an eccentric entry portal, problems with reaming, binding of the nail, iatrogenic comminution of the fracture, distraction of the fragments, extrusion of the nail into the soft tissues, injury of the femoral or popliteal artery, traction palsy of the sciatic or pudendal nerve, and penetration of the knee joint by the nail1-4,7-9,11-13,16-23. We report the cases of two patients in whom a fragment of cortical bone became trapped in the open tip of an intramedullary nail and was driven into the knee joint during nailing of the femur.

*No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article. No funds were received in support of this study.

†University of Kentucky Sports Medicine, Kentucky Clinic, Room K431, Lexington, Kentucky 40536-0284.

‡University of Southern California, Southern California Orthopaedic Institute, Van Nuys, California 91405.

*No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article. No funds were received in support of this study.
†University of Kentucky Sports Medicine, Kentucky Clinic, Room K431, Lexington, Kentucky 40536-0284.
‡University of Southern California, Southern California Orthopaedic Institute, Van Nuys, California 91405.
 
Anchor for JumpAnchor for Jump
+Figs. 1-A, 1-B, and 1-C: Case 1. Fig. 1-A: Anteroposterior radiograph showing a comminuted fracture of the femur with intra-articular extension.
 
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+Fig. 1-B Anteroposterior and lateral radiographs of the knee after intramedullary nailing with static locking and placement of an additional transcondylar screw. A fragment of cortical bone is seen to be protruding through the intercondylar notch at the tip of the intramedullary nail (arrowheads).
 
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+Fig. 1-C Intraoperative photograph showing the fragment of cortical bone (arrows) within the intercondylar notch before it was removed.
 
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+Figs. 2-A, 2-B, and 2-C: Case 2. Fig. 2-A: Anteroposterior and lateral radiographs showing a transverse fracture of the femoral shaft with type-I comminution26.
 
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+Fig. 2-B: Anteroposterior and lateral radiographs made after intramedullary nailing with static locking, showing a spike of cortical bone (arrowheads) in the tip of the intramedullary nail penetrating the knee joint (arrows).
 
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+Fig. 2-C Intraoperative photograph showing the cortical fragment (arrows) protruding through the intercondylar notch.
CASE 1. A forty-five-year-old man was in a motorcycle accident and sustained a grade-II open, comminuted, supracondylar fracture of the femur10 and that extended into the intercondylar notch (Fig. 1-A). The fracture was irrigated and debrided, and two percutaneous cancellous-bone lag-screws, 6.5 millimeters in diameter, were inserted to stabilize the articular surface. After seven days of skeletal traction with use of a tibial pin, closed nailing of the femur with static locking was performed5. Before the operation, 1.5 centimeters of the distal end of a thirteen-millimeter-diameter intramedullary nail was cut off to ensure placement of two distal locking screws into the condylar fragments14. The 6.5-millimeter-diameter lag-screw that had been placed proximally at the time of the initial operation was removed before the nailing.
Postoperative radiographs made in the recovery room revealed a fragment of cortical bone protruding through the fracture in the intercondylar notch (Fig. 1-B). Three days later, an arthrotomy with wide exposure of the joint was performed. At the time of the operation, a two-centimeter fragment of cortical bone protruding through the intercondylar notch was removed with use of a small osteotome and rongeur (Fig. 1-C). There was a three-millimeter separation of the condyles in the intercondylar notch. No other intra-articular abnormality was noted, and the reduction of the fracture was not revised. At the three-year follow-up examination, the fracture had united with 10 degrees of apex-posterior angulation, the knee had a range of motion of 5 degrees of hyperextension to 110 degrees of flexion, and the patient had returned to work as a laborer.
CASE 2. An eighteen-year-old woman was in a motorcycle accident and sustained multiple orthopaedic injuries, including a closed fracture of the proximal third of the femur with type-I comminution26 (Fig. 2-A). Treatment at another facility consisted of insertion of an eleven-millimeter-diameter Kuntscher nail through the tip of the greater trochanter with use of a closed technique; the nail was not locked. Postoperatively, the patient was noted to have an external rotational deformity of the lower limb and was referred to our institution for additional treatment. On physical examination, this deformity was found to be 40 degrees. One week after the injury, the Küntscher nail was removed and intraoperative correction of the rotational deformity was performed through the fracture site with use of closed manipulation and insertion of a twelve-millimeter-diameter locking nail over a three-millimeter-diameter guide-wire. The nail was locked proximally and distally. The original trochanteric entry portal of the Küntscher nail was used during the exchange nailing, leading to iatrogenic comminution of the medial cortex of the proximal part of the femur. Radiographs made at the conclusion of the operation revealed a fragment of cortical bone protruding from the intercondylar notch (Fig. 2-B). An arthrotomy of the knee was performed, and a 1.5-centimeter spike of bone was removed with use of a small osteotome (Fig. 2-C). At the one-year follow-up examination, the fracture had healed and the knee had a full range of motion.
To our knowledge, we are the first to report a complication of nailing in which a fragment of cortical bone became trapped within the open tip of the intramedullary nail and was driven down the femoral canal through the intercondylar notch and into the knee joint. We speculated that in our first patient (Case 1) the fragment of cortical bone became lodged in the distal part of the femoral canal at the time of the injury. However, it is possible that it was displaced into the canal either by the intramedullary guide-wire or by the reamers. During nailing, the guide-wire may have migrated proximally, allowing a fracture fragment to become trapped in the open tip of the nail. In addition, the removal of 1.5 centimeters of the distal part of the nail before its insertion eliminated the taper on the nail and may have predisposed it to trapping the fragment of bone. This untoward event may have been avoided if the fracture had been stabilized with plates and screws. However, recent reports have shown intramedullary nailing of a fracture of the distal part of the femur to have mechanical and biological advantages compared with plate osteosynthesis6,14. In our second patient (Case 2), additional comminution of the fracture occurred during exchange nailing. We attributed this to the lateral entry point in the trochanter and to eccentric reaming. The three-millimeter-diameter guide-wire was insufficient to prevent a fracture fragment from becoming stuck in the tip of the nail and subsequently violating the knee joint. The case of this patient emphasizes the importance of establishing an entry point directly in line with the medullary canal in order to minimize the risk of iatrogenic comminution during reaming or nailing12.
In an effort to minimize the risk of inadvertent penetration of the knee joint by a fragment of bone, we recommend the careful evaluation of preoperative radiographs in order to assess the degree and location of comminuted fracture fragments and non-displaced fracture lines; the use of high-quality biplanar imaging of the fracture site during passage of the guide-wire as well as during reaming and nailing in order to prevent or detect additional comminution of the fracture; and the use of full-length radiographs of the femur, including the hip and the knee joint, made after the conclusion of the operation but while the patient is still under anesthesia11. Making such radiographs after nailing allows assessment of the implant, the alignment of the fracture, and the length of the limb as well as visualization of the femoral neck and the knee joint to rule out an associated fracture. Only after the radiographs have been carefully reviewed to verify that the placement of the nail and the reduction of the fracture are correct can an operation be safely terminated. This practice ensures that any technical complications can be corrected during the same anesthesia session, thereby avoiding a second procedure.
Benirschke, S. K.; Melder, I.; Henley, M. B.; Routt, M. L.; Smith, D. G.; Chapman, J. R.; and |and |Swiontkowski, M. F.: Closed interlocking nailing of femoral shaft fractures: assessment of technical complications and functional outcomes by comparison of a prospective database with retrospective review. J. Orthop. Trauma,7: 118-122, 1993.7118  1993  [PubMed][CrossRef]
 
Böhler, J.: Results in medullary nailing of ninety-five fresh fractures of the femur. J. Bone and Joint Surg.,33-A: 670-678, July 1951.33-A670  1951 
 
Böhler, J.: Closed intramedullary nailing of the femur. Clin. Orthop.,60: 51-67, 1968.6051  1968  [PubMed]
 
Browner, B. D.: Pitfalls, errors, and complications in the use of locking Kuntscher nails. Clin. Orthop.,212: 192-208, 1986.212192  1986  [PubMed]
 
Brumback, R. J.; Ellison, P. S., Jr.; Poka, A.; Lakatos, R.; Bathon, G. H.; and |and |Burgess, A. R.: Intramedullar nailing of open fractures of the femoral shaft. J. Bone and Joint Surg.,71-A: 1324-1331, Oct. 1989.71-A1324  1989 
 
Butler, M. S.; Brumback, R. J.; Ellison, T. S.; Poka, A.; Bathon, G. H.; and |and |Burgess, A. R.: Interlocking intramedullary nailing for ipsilateral fractures of the femoral shaft and distal part of the femur. J. Bone and Joint Surg.,73-A: 1492-1502, Dec. 1991.73-A1492  1991 
 
Clawson, D. K.; Smith, R. F.; and |and |Hansen, S. T.: Closed intramedullary nailing of the femur. J. Bone and Joint Surg.,53-A: 681-692, June 1971.53-A681  1971 
 
Dencker, H.: Errors in technique and complications specific to intramedullary nailing. Acta Orthop. Scandinavica,35: 164-169, 1964.35164  1964  [CrossRef]
 
Dickson, J. W.: False aneurysm after intramedullary nailing of the femur. J. Bone and Joint Surg.,50-B(1): 144-145, 1968.50-B(1)144  1968 
 
Gustilo, R. B., and |and |Anderson, J. T.: Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones. Retrospective and prospective analyses. J. Bone and Joint Surg.,58-A: 453-458, June 1976.58-A453  1976 
 
Johnson, K. D.: Femoral shaft fractures. In Skeletal Trauma. Fractures, Dislocations, Ligamentous Injuries, pp. 1525-1641. Edited by B. D. Browner, J. B. Jupiter, A. M. Levine, and P. G. Trafton. Philadelphia, W. B. Saunders, 1992. 
 
Johnson, K. D.; Johnston, D. W. C.; and |and |Parker, B.: Comminuted femoral-shaft fractures: treatment by roller traction, cerclage wires and an intramedullary nail, or an interlocking intramedullary nail. J. Bone and Joint Surg.,66-A: 1222-1235, Oct. 1984.66-A1222  1984 
 
Kempf, I.; Grosse, A.; and |and |Beck, G.: Closed locked intramedullary nailing. Its application to comminuted fractures of the femur. J. Bone and Joint Surg.,67-A: 709-720, June 1985.67-A709  1985 
 
Leung, K. S.; Shen, W. Y.; So, W. S.; Mui, L. T.; and |and |Grosse, A.: Interlocking intramedullary nailing for supracondylar and intercondylar fractures of the distal part of the femur. J. Bone and Joint Surg.,73-A: 332-340, March 1991.73-A332  1991 
 
Lhowe, D. W., and |and |Hansen, S. T.: Immediate nailing of open fractures of the femoral shaft. J. Bone and Joint Surg.,70-A: 812-820, July 1988.70-A812  1988 
 
Lottes, J. O., and |and |Key, J. A.: Complications and errors in technic in medullary nailing for fractures of the femur. Clin. Orthop.,2: 38-49, 1953.238  1953  [PubMed]
 
Palmer, I.: Review of the complications and technical problems of intramedullary nailing. J. Bone and Joint Surg.,32-B(4): 721-729, 1950.32-B(4)721  1950 
 
Patterson, A. H., and |and |Scott, W. N.: Ten years' experience with femoral shaft fractures. J. Trauma,15: 348-355, 1975.15348  1975  [PubMed][CrossRef]
 
Street, D. M.: Complications in medullary nailing of the femur. Clin. Orthop.,2: 93-101, 1953.293  1953  [PubMed]
 
Stuck, W. G., and Thompson, M. S.: Complications of intramedullary fixation of fractures of the femur. Read at the Annual Meeting of the American Medical Association, San Francisco, California, June 29, 1950. 
 
Vesely, D. G.: Editorial comment. 30 years of experience with intramedullary fixation for fractures of the femur. Clin. Orthop.,60: 3-4, 1968.603  1968  [PubMed]
 
Watson-Jones, R.: Medullary nailing of fractures after fifty years. With a review of the difficulties and complications of the operation. J. Bone and Joint Surg.,32-B(4): 694-698, 1950.32-B(4)694  1950 
 
Wickstrom, J.; Corban, M. S.; and |and |Vise, G. T., Jr.: Complications following intramedullary fixation of 324 fractured femurs. Clin. Orthop.,60: 103-113, 1968.60103  1968  [PubMed]
 
Winquist, R. A.: Locked femoral nailing. J. Am. Acad. Orthop. Surgeons,1: 95-105, 1993.195  1993 
 
Winquist, R. A., and |and |Hansen, S. T., Jr.: Comminuted fractures of the femoral shaft treated by intramedullary nailing. Orthop. Clin. North America,11: 633-648, 1980.11633  1980 
 
Winquist, R. A.; Hansen, S. T., Jr.; and |and |Clawson, D. K.: Closed intramedullary nailing of femoral fractures. A report of five hundred and twenty cases. J. Bone and Joint Surg.,66-A: 529-539, April 1984.66-A529  1984 
 
Wiss, D. A.; Brien, W. W.; and |and |Becker, V., Jr.: Interlocking nailing for the treatment of femoral fractures due to gunshot wounds. J. Bone and Joint Surg.,73-A: 598-606, April 1991.73-A598  1991 
 
Wiss, D. A.; Brien, W. W.; and |and |Stetson, W. B.: Interlocked nailing for treatment of segmental fractures of the femur. J. Bone and Joint Surg.,72-A: 724-728, June 1990.72-A724  1990 
 
Wiss, D. A.; Brumback, R. J.; Kyle, R. F.; and |and |Winquist, R. A.: Symposium: current concepts in femoral nailing. Contemp. Orthop.,26: 177-214, 1993.26177  1993 
 
Wiss, D. A.; Fleming, C. H.; Matta, J. M.; and |and |Clark, D.: Comminuted and rotationally unstable fractures of the femur treated with an interlocking nail. Clin. Orthop.,212: 35-47, 1986.21235  1986  [PubMed]
 
Wu, C. C., and |and |Shih, C. H.: Interlocking nailing of distal femoral fractures. 28 patients followed for 1-2 years. Acta Orthop. Scandinavica,62: 342-345, 1991.62342  1991  [CrossRef]
 

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Anchor for JumpAnchor for Jump
+Figs. 1-A, 1-B, and 1-C: Case 1. Fig. 1-A: Anteroposterior radiograph showing a comminuted fracture of the femur with intra-articular extension.
Anchor for JumpAnchor for Jump
+Fig. 1-B Anteroposterior and lateral radiographs of the knee after intramedullary nailing with static locking and placement of an additional transcondylar screw. A fragment of cortical bone is seen to be protruding through the intercondylar notch at the tip of the intramedullary nail (arrowheads).
Anchor for JumpAnchor for Jump
+Fig. 1-C Intraoperative photograph showing the fragment of cortical bone (arrows) within the intercondylar notch before it was removed.
Anchor for JumpAnchor for Jump
+Figs. 2-A, 2-B, and 2-C: Case 2. Fig. 2-A: Anteroposterior and lateral radiographs showing a transverse fracture of the femoral shaft with type-I comminution26.
Anchor for JumpAnchor for Jump
+Fig. 2-B: Anteroposterior and lateral radiographs made after intramedullary nailing with static locking, showing a spike of cortical bone (arrowheads) in the tip of the intramedullary nail penetrating the knee joint (arrows).
Anchor for JumpAnchor for Jump
+Fig. 2-C Intraoperative photograph showing the cortical fragment (arrows) protruding through the intercondylar notch.
Benirschke, S. K.; Melder, I.; Henley, M. B.; Routt, M. L.; Smith, D. G.; Chapman, J. R.; and |and |Swiontkowski, M. F.: Closed interlocking nailing of femoral shaft fractures: assessment of technical complications and functional outcomes by comparison of a prospective database with retrospective review. J. Orthop. Trauma,7: 118-122, 1993.7118  1993  [PubMed][CrossRef]
 
Böhler, J.: Results in medullary nailing of ninety-five fresh fractures of the femur. J. Bone and Joint Surg.,33-A: 670-678, July 1951.33-A670  1951 
 
Böhler, J.: Closed intramedullary nailing of the femur. Clin. Orthop.,60: 51-67, 1968.6051  1968  [PubMed]
 
Browner, B. D.: Pitfalls, errors, and complications in the use of locking Kuntscher nails. Clin. Orthop.,212: 192-208, 1986.212192  1986  [PubMed]
 
Brumback, R. J.; Ellison, P. S., Jr.; Poka, A.; Lakatos, R.; Bathon, G. H.; and |and |Burgess, A. R.: Intramedullar nailing of open fractures of the femoral shaft. J. Bone and Joint Surg.,71-A: 1324-1331, Oct. 1989.71-A1324  1989 
 
Butler, M. S.; Brumback, R. J.; Ellison, T. S.; Poka, A.; Bathon, G. H.; and |and |Burgess, A. R.: Interlocking intramedullary nailing for ipsilateral fractures of the femoral shaft and distal part of the femur. J. Bone and Joint Surg.,73-A: 1492-1502, Dec. 1991.73-A1492  1991 
 
Clawson, D. K.; Smith, R. F.; and |and |Hansen, S. T.: Closed intramedullary nailing of the femur. J. Bone and Joint Surg.,53-A: 681-692, June 1971.53-A681  1971 
 
Dencker, H.: Errors in technique and complications specific to intramedullary nailing. Acta Orthop. Scandinavica,35: 164-169, 1964.35164  1964  [CrossRef]
 
Dickson, J. W.: False aneurysm after intramedullary nailing of the femur. J. Bone and Joint Surg.,50-B(1): 144-145, 1968.50-B(1)144  1968 
 
Gustilo, R. B., and |and |Anderson, J. T.: Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones. Retrospective and prospective analyses. J. Bone and Joint Surg.,58-A: 453-458, June 1976.58-A453  1976 
 
Johnson, K. D.: Femoral shaft fractures. In Skeletal Trauma. Fractures, Dislocations, Ligamentous Injuries, pp. 1525-1641. Edited by B. D. Browner, J. B. Jupiter, A. M. Levine, and P. G. Trafton. Philadelphia, W. B. Saunders, 1992. 
 
Johnson, K. D.; Johnston, D. W. C.; and |and |Parker, B.: Comminuted femoral-shaft fractures: treatment by roller traction, cerclage wires and an intramedullary nail, or an interlocking intramedullary nail. J. Bone and Joint Surg.,66-A: 1222-1235, Oct. 1984.66-A1222  1984 
 
Kempf, I.; Grosse, A.; and |and |Beck, G.: Closed locked intramedullary nailing. Its application to comminuted fractures of the femur. J. Bone and Joint Surg.,67-A: 709-720, June 1985.67-A709  1985 
 
Leung, K. S.; Shen, W. Y.; So, W. S.; Mui, L. T.; and |and |Grosse, A.: Interlocking intramedullary nailing for supracondylar and intercondylar fractures of the distal part of the femur. J. Bone and Joint Surg.,73-A: 332-340, March 1991.73-A332  1991 
 
Lhowe, D. W., and |and |Hansen, S. T.: Immediate nailing of open fractures of the femoral shaft. J. Bone and Joint Surg.,70-A: 812-820, July 1988.70-A812  1988 
 
Lottes, J. O., and |and |Key, J. A.: Complications and errors in technic in medullary nailing for fractures of the femur. Clin. Orthop.,2: 38-49, 1953.238  1953  [PubMed]
 
Palmer, I.: Review of the complications and technical problems of intramedullary nailing. J. Bone and Joint Surg.,32-B(4): 721-729, 1950.32-B(4)721  1950 
 
Patterson, A. H., and |and |Scott, W. N.: Ten years' experience with femoral shaft fractures. J. Trauma,15: 348-355, 1975.15348  1975  [PubMed][CrossRef]
 
Street, D. M.: Complications in medullary nailing of the femur. Clin. Orthop.,2: 93-101, 1953.293  1953  [PubMed]
 
Stuck, W. G., and Thompson, M. S.: Complications of intramedullary fixation of fractures of the femur. Read at the Annual Meeting of the American Medical Association, San Francisco, California, June 29, 1950. 
 
Vesely, D. G.: Editorial comment. 30 years of experience with intramedullary fixation for fractures of the femur. Clin. Orthop.,60: 3-4, 1968.603  1968  [PubMed]
 
Watson-Jones, R.: Medullary nailing of fractures after fifty years. With a review of the difficulties and complications of the operation. J. Bone and Joint Surg.,32-B(4): 694-698, 1950.32-B(4)694  1950 
 
Wickstrom, J.; Corban, M. S.; and |and |Vise, G. T., Jr.: Complications following intramedullary fixation of 324 fractured femurs. Clin. Orthop.,60: 103-113, 1968.60103  1968  [PubMed]
 
Winquist, R. A.: Locked femoral nailing. J. Am. Acad. Orthop. Surgeons,1: 95-105, 1993.195  1993 
 
Winquist, R. A., and |and |Hansen, S. T., Jr.: Comminuted fractures of the femoral shaft treated by intramedullary nailing. Orthop. Clin. North America,11: 633-648, 1980.11633  1980 
 
Winquist, R. A.; Hansen, S. T., Jr.; and |and |Clawson, D. K.: Closed intramedullary nailing of femoral fractures. A report of five hundred and twenty cases. J. Bone and Joint Surg.,66-A: 529-539, April 1984.66-A529  1984 
 
Wiss, D. A.; Brien, W. W.; and |and |Becker, V., Jr.: Interlocking nailing for the treatment of femoral fractures due to gunshot wounds. J. Bone and Joint Surg.,73-A: 598-606, April 1991.73-A598  1991 
 
Wiss, D. A.; Brien, W. W.; and |and |Stetson, W. B.: Interlocked nailing for treatment of segmental fractures of the femur. J. Bone and Joint Surg.,72-A: 724-728, June 1990.72-A724  1990 
 
Wiss, D. A.; Brumback, R. J.; Kyle, R. F.; and |and |Winquist, R. A.: Symposium: current concepts in femoral nailing. Contemp. Orthop.,26: 177-214, 1993.26177  1993 
 
Wiss, D. A.; Fleming, C. H.; Matta, J. M.; and |and |Clark, D.: Comminuted and rotationally unstable fractures of the femur treated with an interlocking nail. Clin. Orthop.,212: 35-47, 1986.21235  1986  [PubMed]
 
Wu, C. C., and |and |Shih, C. H.: Interlocking nailing of distal femoral fractures. 28 patients followed for 1-2 years. Acta Orthop. Scandinavica,62: 342-345, 1991.62342  1991  [CrossRef]
 
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