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Progressive Genu Valgum Secondary to a Fibrous Tether at the Distal Aspect of the Femur. A Case Report*
SANTIAGO AMILLO, M.D.†; GONZALO MORA, M.D.†; PATRICIO LÉNIZ, M.D.†, PAMPLONA, SPAIN
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Investigation performed at the Department of Orthopaedic Surgery and Traumatology, University Clinic of Navarra, Pamplona
The Journal of Bone & Joint Surgery.  1998; 80:424-7 
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Bilateral angular deformity of the lower extremity in children is common, and it is often due to benign physiological conditions in which the deformity corrects with growth1,2. However, unilateral angular deformity is rare and usually involves an abnormal condition such as Blount disease, fibrous dysplasia, Ollier disease, dyschondrosteosis, neurofibromatosis, a growth disturbance resulting from a physeal injury or infection, or even a rare condition described as tibia vara caused by focal fibrocartilaginous dysplasia2. To our knowledge, only five children with unilateral angular deformity of the distal end of the femur secondary to a focal fibrous tether have been described in the literature, and only two of them had a valgus deformity1,3.
We describe a boy who had a progressive genu valgum secondary to a tether of fibrous tissue, confirmed by histological examination, at the distal end of the femur.

*No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article. No funds were received in support of this study.

†Department of Orthopaedic Surgery and Traumatology, University Clinic of Navarra, Avenue Pio XII 36, 31008 Pamplona, Spain. E-mail address for Dr. Mora: gmorag@cun.unav.es.

*No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article. No funds were received in support of this study.
†Department of Orthopaedic Surgery and Traumatology, University Clinic of Navarra, Avenue Pio XII 36, 31008 Pamplona, Spain. E-mail address for Dr. Mora: gmorag@cun.unav.es.
 
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+Fig. 1: Preoperative radiograph, made when the patient was eighteen months old, showing a valgus deformity with a tibiofemoral angle of 24 degrees. The femur appears to be shortened.
 
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+Fig. 2: Postoperative radiograph, made when the patient was twenty-seven months old, showing progressive recurrence of the valgus deformity with a tibiofemoral angle of 40 degrees. Note the abnormal valgus orientation of the distal femoral physis.
 
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+Fig. 3: Radiograph made after performance of a lateral percutaneous osteotomy and fixation with a unilateral external fixator when the child was twenty-nine months old. The alignment of the lower extremity is apparently normal, but the tibia is in 5 degrees of valgus angulation in relation to the distal femoral epiphysis.
 
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+Fig. 4: Radiograph made after the second operation, when the patient was three years and eight months old, showing a new progressive recurrence of the valgus deformity with a tibiofemoral angle of 26 degrees. Again, the distal femoral physis has an abnormal valgus orientation.
 
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+Fig. 5-A: Coronal T1 and T2-weighted magnetic resonance imaging scans through the middle portion of the knee, made when the child was three years and eight months old, showing asymmetry of the femoral condyles and lateral deviation of the patella. There are multiple areas of low signal intensity (arrow) in the lateral aspect of the femur, resulting from the previous operations. The area of high signal intensity lateral to the femur represents the fibrous tether, which was confirmed after the last operation.
 
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+Fig. 6 Radiograph made when the patient was eight years and four months old, showing normal alignment of the extremity with no shortening.
 
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+Fig. 5-B: Coronal T1 and T2-weighted magnetic resonance imaging scans through the middle portion of the knee, made when the child was three years and eight months old, showing asymmetry of the femoral condyles and lateral deviation of the patella. There are multiple areas of low signal intensity (arrow) in the lateral aspect of the femur, resulting from the previous operations. The area of high signal intensity lateral to the femur represents the fibrous tether, which was confirmed after the last operation.
 
Anchor for JumpAnchor for Jump  TABLE I SUMMARY OF REPORTED DATA ON PATIENTS WHO HAD UNILATERAL ANGULAR DEFORMITY OF THE LOWER LIMB
Findings in Femur
StudyCaseGender, Age (Mos.)SideType of DeformityRadiographicOther Imaging StudiesHistologicalTreatmentComments
Beaty and Barrett (1989)1M, 30RValgusDefined linear defect in distal metaphysis; valgus deformity at same levelTc-99 bone scan: reactive lesion in distal end at site of radiographic changes; no evidence of other activityHypocellular dense collagenous tissueLateral opening-wedge femoral osteotomy and excision of fibrous band (0.5 x 6 cm) at 54 mos.First noted at 12 mos.; fibrous band arising from tunnel in bone and inserting distally in prox. part of distal physis; no recurrence after 3 yrs.
2M, 42LVarusUnusual thickening and angulation of bone in medial aspect of distal metaphysisTc-99 bone scan: increased uptake at site of radiographic changesHypocellular dense collagenous tissueLateral closing-wedge femoral osteotomy by another surgeon at 24 mos.; medial opening-wedge osteotomy and excision of fibrous band (0.5 x 5 cm) at 5 yrs. + 9 mos.First noted at 12 months; rapid recurrence 1 yr. after first osteotomy; fibrous band arising from tunnel in bone and inserting distally in prox. part of distal physis; no recurrence after the second osteotomy
3F, 13RVarusDefect on medial aspect of distal endNo biopsyMedial opening-wedge osteotomy and excision of fibrous band (2 x 4 cm)Fibrous band arising from tunnel in bone and inserting distally in prox. part of distal physis; treated early because of remote possibility of neoplastic process; no recurrence after 6 yrs.
4M, 9RValgusLesion on lateral aspect of distal endHypocellular dense collagenous tissueLateral opening-wedge osteotomy and excision of fibrous band (1 x 5 cm)Fibrous band arising from tunnel in bone and inserting distally in prox. part of distal physis; treated early because of remote possibility of neoplastic process; no recurrence after 5 yrs.
Vallcanera et al. (1994)5M, 13RVarusCortical defect with sclerotic margins on medial sideComputed tomographic scan: defect in medial cortex with small mass with soft-tissue densityFibrous tissueValgus osteotomy and excision of fibrous bandFirst noted at 2 mos.
Present study (1998)6M, 27RValgusSclerosis at external part of distal metaphysis secondary to first osteotomyMagnetic resonance imaging: mass with soft-tissue signal intensity at lateral aspect of distal endFibrous tissueVarus osteotomy by another surgeon at 18 mos.; varus osteotomy at 27 mos.; varus osteotomy and excision of fibrous band (1.2 x 10 cm) at 44 mos.Rapid recurrence 6 mos. after first osteotomy; recurrence 15 mos. after second osteotomy; no recurrence 5 yrs. after third procedure
A twenty-seven-month-old boy was referred to us for evaluation of a valgus deformity of the distal aspect of the right femur. The mother had first noted the deformity when the child was twelve months old. At that time, the tibiofemoral angle measured 18 degrees radiographically.
When the boy was eighteen months old, the tibiofemoral angle was 24 degrees (Fig. 1) and a varus osteotomy and a tenotomy of the iliotibial tract was performed by another surgeon. A biopsy of the bone revealed normal findings. The deformity recurred nine months later, with a resultant tibiofemoral angle measuring 40 degrees of valgus radiographically (Fig. 2).
When we first saw the patient, physical examination revealed a limp and 40 degrees of genu valgum in the right lower limb. Radiographs showed sclerosis at the lateral aspect of the distal metaphysis of the right femur, secondary to the previous biopsy and osteotomy, and the valgus deformity. At that time, a lateral percutaneous varus osteotomy of the distal end of the femur was performed and a Wagner external fixator was applied. After the osteotomy, the extremity was well aligned with 5 degrees of physiological valgus angulation. The fixator was removed two months postoperatively (Fig. 3).
Fifteen months later, the deformity recurred and the tibiofemoral angle measured 26 degrees of valgus (Fig. 4). At that time, magnetic resonance imaging showed a mass of high signal intensity consistent with soft tissue on the lateral aspect of the distal end of the femur (Figs. 5-A and 5-B). The tissue was difficult to evaluate because of the two previous operations in that area. Another operation was performed because of progression of the deformity, and a fibrous band (1.2 by ten centimeters) was found at the lateral aspect of the femur, from the diaphysis to the distal femoral epiphysis. The band was removed completely. An opening-wedge osteotomy of the distal end of the femur was performed, and the site of the osteotomy was fixed with Blount staples. A cylinder cast that extended from the groin to the foot was worn for forty days. Histological examination of the excised band showed well organized dense fibrous tissue. Five years after the operation, the alignment of the extremity was normal (Fig. 6).
Beaty and Barrett, in 1989, were apparently the first to describe a lesion similar to the one in our patient. They reported on four children who had an angular deformity of the distal part of the femur secondary to an unusual fibrous tether. According to its medial or lateral location, this tether produced a varus or valgus deformity of the distal end of the femur; two children had a varus deformity and two, a valgus deformity (Table I). The deformity was painless, and none of the patients had a history of injury, infection, or any other abnormal condition.
More recently, in 1994, Vallcanera et al. described a similar lesion that caused a varus deformity at the distal end of the femur (Table I). As in our patient, the deformity in the five children described by Beaty and Barrett and Vallcanera et al. was located at the distal end of the femur and did not improve spontaneously. Because the deformity progressed, all six patients needed a corrective osteotomy and an excision of the fibrous band. Excision of the band is necessary because, without it, the deformity returns. It is interesting to speculate whether a deformity that is not severe could be corrected with excision of the fibrous band alone (that is, without an osteotomy).
The origin of the fibrous tether is unknown. Beaty and Barrett stated that they could "only speculate as to the etiology of this lesion, but possible explanations include occult trauma near the metaphysis or physis, an extensive subperiosteal fibroma with intraosseous extension (although the lesion we are reporting has a different pathology), and a remnant of accessory muscle." We believe, as did those authors, that although this lesion is rare it should be recognized as a possible cause of unilateral angular deformity, especially when radiographs reveal cortical irregularities or a tunnel-like lesion in association with the angular deformity.
Operative correction should be considered when progression of the deformity has been confirmed, as is recommended for the treatment of infantile Blount disease. Lesions in the region of the distal end of the femur should be investigated for the possibility of a fibrous tether, and we believe that magnetic resonance imaging may help in the identification of such a tether. In our patient, an operation to remove the fibrous band was necessary because it was the basic cause of the deformity.
Beaty, J. H., and Barrett, I. R.: Unilateral angular deformity of the distal end of the femur secondary to a focal fibrous tether. A report of four cases. J. Bone and Joint Surg.,71-A: 440-445, March 1989.71-A440  1989 
 
Bell, S. N.; Campbell, P. E.; Cole, W. G.; and Menelaus, M. B.: Tibia vara caused by focal fibrocartilaginous dysplasia. Three case reports. J. Bone and Joint Surg.,67-B(5): 780-784, 1985.67-B(5)780  1985 
 
Vallcanera, C. A.; Sanguesa, N. C.; Martinez, F. M.; and Cortina, O. H.: Varus deformity of the distal end of the femur secondary to a focal fibrous lesion. Pediat. Radiol.,24: 74-75, 1994.2474  1994  [PubMed]
 

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+Fig. 1: Preoperative radiograph, made when the patient was eighteen months old, showing a valgus deformity with a tibiofemoral angle of 24 degrees. The femur appears to be shortened.
Anchor for JumpAnchor for Jump
+Fig. 2: Postoperative radiograph, made when the patient was twenty-seven months old, showing progressive recurrence of the valgus deformity with a tibiofemoral angle of 40 degrees. Note the abnormal valgus orientation of the distal femoral physis.
Anchor for JumpAnchor for Jump
+Fig. 3: Radiograph made after performance of a lateral percutaneous osteotomy and fixation with a unilateral external fixator when the child was twenty-nine months old. The alignment of the lower extremity is apparently normal, but the tibia is in 5 degrees of valgus angulation in relation to the distal femoral epiphysis.
Anchor for JumpAnchor for Jump
+Fig. 4: Radiograph made after the second operation, when the patient was three years and eight months old, showing a new progressive recurrence of the valgus deformity with a tibiofemoral angle of 26 degrees. Again, the distal femoral physis has an abnormal valgus orientation.
Anchor for JumpAnchor for Jump
+Fig. 5-A: Coronal T1 and T2-weighted magnetic resonance imaging scans through the middle portion of the knee, made when the child was three years and eight months old, showing asymmetry of the femoral condyles and lateral deviation of the patella. There are multiple areas of low signal intensity (arrow) in the lateral aspect of the femur, resulting from the previous operations. The area of high signal intensity lateral to the femur represents the fibrous tether, which was confirmed after the last operation.
Anchor for JumpAnchor for Jump
+Fig. 6 Radiograph made when the patient was eight years and four months old, showing normal alignment of the extremity with no shortening.
Anchor for JumpAnchor for Jump
+Fig. 5-B: Coronal T1 and T2-weighted magnetic resonance imaging scans through the middle portion of the knee, made when the child was three years and eight months old, showing asymmetry of the femoral condyles and lateral deviation of the patella. There are multiple areas of low signal intensity (arrow) in the lateral aspect of the femur, resulting from the previous operations. The area of high signal intensity lateral to the femur represents the fibrous tether, which was confirmed after the last operation.
Anchor for JumpAnchor for Jump  TABLE I SUMMARY OF REPORTED DATA ON PATIENTS WHO HAD UNILATERAL ANGULAR DEFORMITY OF THE LOWER LIMB
Findings in Femur
StudyCaseGender, Age (Mos.)SideType of DeformityRadiographicOther Imaging StudiesHistologicalTreatmentComments
Beaty and Barrett (1989)1M, 30RValgusDefined linear defect in distal metaphysis; valgus deformity at same levelTc-99 bone scan: reactive lesion in distal end at site of radiographic changes; no evidence of other activityHypocellular dense collagenous tissueLateral opening-wedge femoral osteotomy and excision of fibrous band (0.5 x 6 cm) at 54 mos.First noted at 12 mos.; fibrous band arising from tunnel in bone and inserting distally in prox. part of distal physis; no recurrence after 3 yrs.
2M, 42LVarusUnusual thickening and angulation of bone in medial aspect of distal metaphysisTc-99 bone scan: increased uptake at site of radiographic changesHypocellular dense collagenous tissueLateral closing-wedge femoral osteotomy by another surgeon at 24 mos.; medial opening-wedge osteotomy and excision of fibrous band (0.5 x 5 cm) at 5 yrs. + 9 mos.First noted at 12 months; rapid recurrence 1 yr. after first osteotomy; fibrous band arising from tunnel in bone and inserting distally in prox. part of distal physis; no recurrence after the second osteotomy
3F, 13RVarusDefect on medial aspect of distal endNo biopsyMedial opening-wedge osteotomy and excision of fibrous band (2 x 4 cm)Fibrous band arising from tunnel in bone and inserting distally in prox. part of distal physis; treated early because of remote possibility of neoplastic process; no recurrence after 6 yrs.
4M, 9RValgusLesion on lateral aspect of distal endHypocellular dense collagenous tissueLateral opening-wedge osteotomy and excision of fibrous band (1 x 5 cm)Fibrous band arising from tunnel in bone and inserting distally in prox. part of distal physis; treated early because of remote possibility of neoplastic process; no recurrence after 5 yrs.
Vallcanera et al. (1994)5M, 13RVarusCortical defect with sclerotic margins on medial sideComputed tomographic scan: defect in medial cortex with small mass with soft-tissue densityFibrous tissueValgus osteotomy and excision of fibrous bandFirst noted at 2 mos.
Present study (1998)6M, 27RValgusSclerosis at external part of distal metaphysis secondary to first osteotomyMagnetic resonance imaging: mass with soft-tissue signal intensity at lateral aspect of distal endFibrous tissueVarus osteotomy by another surgeon at 18 mos.; varus osteotomy at 27 mos.; varus osteotomy and excision of fibrous band (1.2 x 10 cm) at 44 mos.Rapid recurrence 6 mos. after first osteotomy; recurrence 15 mos. after second osteotomy; no recurrence 5 yrs. after third procedure
Beaty, J. H., and Barrett, I. R.: Unilateral angular deformity of the distal end of the femur secondary to a focal fibrous tether. A report of four cases. J. Bone and Joint Surg.,71-A: 440-445, March 1989.71-A440  1989 
 
Bell, S. N.; Campbell, P. E.; Cole, W. G.; and Menelaus, M. B.: Tibia vara caused by focal fibrocartilaginous dysplasia. Three case reports. J. Bone and Joint Surg.,67-B(5): 780-784, 1985.67-B(5)780  1985 
 
Vallcanera, C. A.; Sanguesa, N. C.; Martinez, F. M.; and Cortina, O. H.: Varus deformity of the distal end of the femur secondary to a focal fibrous lesion. Pediat. Radiol.,24: 74-75, 1994.2474  1994  [PubMed]
 
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