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Clinical Results of Modular Polyethylene Insert Exchange with Retention of Total Knee Arthroplasty Components*
Gerard A. Engh, M.D.†; Lisa M. Koralewicz, M.P.H.†; Thomas R. Pereles, M.D.‡
View Disclosures and Other Information
Investigation performed at Anderson Orthopaedic Research Institute, Alexandria, Virginia
*No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article. No funds were received in support of this study.
†Anderson Orthopaedic Research Institute, P.O. Box 7088, Alexandria, Virginia 22307.
‡Augusta Medical Center, Suite 110, 93 Medical Center Drive, Fishersville, Virginia 22939.

The Journal of Bone & Joint Surgery.  2000; 82:516-516 
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Abstract

Background: Modular polyethylene inserts have enabled surgeons to perform an isolated tibial insert exchange while retaining well fixed components. The purpose of this study was to review the results of insert revision and to clarify the role of this option compared with that of revision total knee arthroplasty.

Methods: Fifty-six patients (sixty-three knees) were managed with revision of a tibial polyethylene insert and retention of well aligned and stable femoral and tibial components. The implants had been in situ for an average of fifty-nine months (range, two to 108 months) at the time of the insert exchange. The inserts that were removed at the time of exchange were evaluated with regard to wear of the articular surface according to the classification system of Hood et al. and with regard to undersurface wear according to the method described by Wasielewski et al. Forty-eight knees were followed for an average of 7.4 years (range, 3.0 to 12.2 years) after the insert exchange. Knees that did not require an additional operation were considered to have had a successful exchange.

Results: Seven of the forty-eight exchanges failed, at an average of fifty-four months, because of accelerated wear of the new insert. All seven knees required complete revision of all components. Of the twenty-two exchanges that were performed because of severe wear of the primary insert, six (27 percent) failed at an average of less than five years; thus, knees in which the exchange was performed because of advanced wear were more likely to fail again (p < 0.05). In addition, primary inserts that were removed from knees in which the exchange procedure subsequently failed had higher delamination scores than those that were removed from knees in which the exchange was successful (p < 0.05). Most of the primary inserts had substantial undersurface wear at the time of the exchange procedure. Metallosis (thirty knees) and osteolysis (nineteen knees) were unrelated to failure of the exchange.

Conclusions: An isolated revision of the tibial polyethylene insert should not be performed when there is accelerated wear of the insert with severe delamination and grade-3 or 4 undersurface wear within ten years after the primary procedure. Because a variety of patient-related, implant-related, and technical factors influence polyethylene wear, the orthopaedist must consider multiple variables whenever contemplating a limited revision.

Figures in this Article
    The introduction of modular polyethylene inserts in the mid-1980s gave surgeons the option of performing an isolated exchange of the tibial insert while retaining well fixed components. Exchange of the bearing surface offers several potential benefits compared with revision total knee arthroplasty, including maintenance of bone stock, diminished complexity, and lower cost. In addition, rehabilitation is easier because an insert exchange involves less time and blood loss than a complete revision. Moreover, because most patients with polyethylene wear have minimal symptoms, they typically accept an insert exchange but are often reluctant to undergo a total knee revision. Lastly, whereas most failures of so-called first-generation, condylar-type, nonmodular components occur because of aseptic loosening, contemporary modular total knee implants rarely loosen1.
    The most common indications for revision of modular total knee implants are polyethylene wear and secondary osteolysis. In such situations, the orthopaedist must decide whether to retain the stable components - revising only the polyethylene insert - or to perform a complete revision. Despite the widespread use of modular implants, the outcome of isolated insert revision is largely unknown. We sought to clarify the role of isolated insert exchange compared with that of complete revision by reviewing the results of modular insert exchanges that had been performed for a variety of indications.
     
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    +Fig. 1:Photograph of one of the twenty-two inserts that were exchanged because of advanced polyethylene wear, showing extreme delamination of the articular surface and fracture of the polyethylene.
     
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    +Fig. 2:Photograph of one of the twenty-one worn inserts (left) that were exchanged in conjunction with revision of a failed metal-backed patellar component (right).
     
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    +Fig. 3:Photograph of a tibial base-plate (top) and the undersurface of the tibial insert (bottom), showing classic wear-polishing indicated by stippling patterns and metal burnishing. Polyethylene cold flow into the screw-holes and the margins of the tibial tray are indicated by arrows.
     
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    +Fig. 4:Kaplan-Meier survivorship curves for the replacement inserts in knees that had been revised because of the failure of a metal-backed patellar component (Group 1) and for those that had been revised because of polyethylene wear (Group 2). The thin brackets designate the standard error for each curve.
    The senior author (G. A. E.) performed an isolated exchange of a tibial polyethylene insert with retention of the femoral and tibial components in fifty-six patients (sixty-three knees) between February 1987 and September 1995. Seven patients had a bilateral insert exchange. The primary implants had been in situ for an average of fifty-nine months (range, two to 108 months) at the time of the exchange. This option was chosen instead of complete revision if the components were well aligned, showed no evidence of loosening, and had no palpable roughening of the metallic bearing surfaces. No other polyethylene insert exchanges were performed during this interval.
    Eight patients (eight knees) died of unrelated problems less than twenty-four months after the revision (the minimum duration of follow-up for the study. (However, two of these patients had had a bilateral exchange and had at least twenty-four months of follow-up on one side.) Seven patients (seven knees) responded to a telephone survey only and were excluded from the analysis, although all reported that they were doing well and had not had a revision. Forty-three patients (forty-eight knees) had a complete follow-up after a minimum of thirty-six months (average, 7.4 years; range, 3.0 to 12.2 years). We evaluated the clinical records, the fourteen by seventeen-inch (thirty-six by forty-three-centimeter) anteroposterior and lateral radiographs, and the failed components of these patients.
    The average age of the patients was sixty-three years (range, thirty-seven to eighty-four years) at the time of the primary total knee arthroplasty and sixty-eight years (range, forty-three to ninety years) at the time of the insert exchange. Twenty-three patients (twenty-eight knees) were male and twenty patients (twenty knees) were female. The underlying diagnosis was osteoarthritis in forty-one knees, rheumatoid arthritis in six, and septic arthritis in one. The average body-mass index of all patients was twenty-nine kilograms per square meter (range, twenty to forty-three kilograms per square meter).
    The senior author performed forty-five of the forty-eight primary total knee arthroplasties that subsequently were revised with an isolated insert exchange. During the same eight-year period, this surgeon performed a total of 1298 primary total knee arthroplasties. Therefore, 3.5 percent of the primary total knee arthroplasties that were performed by this surgeon subsequently were revised with an insert exchange. The implants that were used for the primary arthroplasties included 118 Porous-Coated Anatomic implants (PCA; Howmedica, Rutherford, New Jersey), 204 Synatomic implants (DePuy, Warsaw, Indiana), and 976 Anatomic Modular Knee implants (AMK; DePuy). The senior author performed 275 knee revisions during this time. Consequently, the forty-eight insert exchanges represented 17 percent of the revision procedures that were performed by this surgeon.
    The main indications for revision of the tibial insert were severe polyethylene wear seen on radiographs (twenty patients, twenty-two knees) (Fig. 1) and wear and damage of the insert noted during revision of a failed metal-backed patellar component (nineteen patients, twenty-one knees) (Fig. 2). (One patient with bilateral knee replacement underwent insert exchange because of severe polyethylene wear in one knee and because of a failed metal-backed patellar component in the other knee.) The remaining five exchanges were performed in conjunction with d衲idement for acute infection (two patients, two knees), treatment of arthrofibrosis (one knee), repair of a ruptured quadriceps tendon (one knee), and treatment of patellar dislocation (one knee).
    Polyethylene wear was identified on standing anteroposterior radiographs without magnification markers. In sixteen knees, extensive polyethylene wear was indicated by a reduction in the space between the femoral component and the tibial base-plate to less than two millimeters. Despite the polyethylene wear seen on radiographs, all patients were asymptomatic. The indication for revision when wear-through had not occurred was the anticipation that wear-through was pending and would damage the femoral component, necessitating total knee revision. Five other patients (five knees) had full-thickness wear of the insert and reported stiffness, low-grade pain, and catching or giving-way of the knee.
    Prior to the revision of the insert, osteolysis had been detected on the anteroposterior and lateral radiographs of ten knees that were revised because of severe polyethylene wear and on the radiographs of nine knees that were revised because of failure of a metal-backed patellar component. The five knees that were revised for other reasons had not exhibited osteolysis.
    The forty-eight knees in the present study had been treated with a variety of modular implants at the time of the primary procedure; these implants included twenty-three Synatomic implants, fifteen AMK implants, eight PCA implants, one Miller-Galante I implant (Zimmer, Warsaw, Indiana), and one Coordinate implant (DePuy). In all knees but one, which had an AMK implant, both the tibial and the femoral component were fixed without cement. The Synatomic and Coordinate tibial inserts were curved in both the anteroposterior and the mediolateral plane. The AMK inserts were curved in the anteroposterior plane. The PCA and Miller-Galante inserts were flat in both planes. The Synatomic, AMK, and Coordinate tibial inserts were secured with a tongue-in-groove locking mechanism and were further stabilized with a central locking pin. The PCA inserts were captured and secured with a locking tab on the tibial tray. The Miller-Galante I insert was secured with a snap-fit with a full peripheral capture on the tibial tray. All of the primary and revision inserts were sterilized with low-dose gamma radiation in air. The primary and revision Synatomic, AMK, and Coordinate inserts were machined from ram-extruded bar stock, the PCA inserts were heat-pressed, and the Miller-Galante I inserts were compression molded. Seven inserts were the largest size available from the manufacturer, and none were the smallest size.
    At the time of the index procedure (the insert exchange), twenty-five metal-backed patellar components were revised, eight patellar components were left in situ, three patellar components were removed without resurfacing the patella, and two patellae were resurfaced for the first time.
    All knees had an extensive synovectomy at the time of the insert exchange, and thirty (63 percent) had clearly visible metallosis. The twenty-one knees with a failed metal-backed patellar component had discoloration of the synovial tissue secondary to metallic debris. Another five knees had metallosis because severe polyethylene wear had resulted in metal-on-metal contact between the femoral component and the tibial base-plate. This contact had caused faint surface scratching and slight burnishing of the femoral component; however, none of these five components had palpable surface roughness. Four other knees had metallosis because the femoral intercondylar notch impinged on the locking pin that was used to stabilize the Synatomic tibial component. These four knees were revised with use of an insert that had a lower central eminence and a recessed pin that did not impinge and wear against the intercondylar notch of the femoral component.
    The average thickness of the tibial insert increased from ten millimeters (range, seven to eighteen millimeters) at the time of the primary procedure to twelve millimeters (range, nine to twenty-five millimeters) at the time of the exchange procedure. In each knee, the thickness of the new insert was determined intraoperatively to provide balanced flexion and extension gaps and varus-valgus stability following appropriate ligament releases. The thickness of the polyethylene insert remained the same in seven knees. It increased by two millimeters in thirty knees and by four millimeters in eleven knees. A Hylamer-M insert was selected for the exchange procedure in four of the forty-eight knees; all four of these knees were in the group in which the revision was performed because of failure of the original tibial insert.
    Forty-two (88 percent) of the forty-eight revised tibial inserts were evaluated with regard to region and mode of wear. (The other six inserts had undergone destructive testing in an unrelated study without having been graded for articular surface wear.) The inserts were divided into anterior and posterior regions, which were subdivided into medial, central, and lateral zones. The six zones were assessed with regard to the seven modes of wear defined by Hood et al.6: surface deformation, pitting, embedded cement debris, scratching, burnishing, abrasion, and delamination. Each mode of wear in each zone was assigned a severity score of 0 points (no wear), 1 point (less than 10 percent wear), 2 points (10 to 50 percent wear), or 3 points (more than 50 percent wear). The overall wear score was the sum of the scores for the individual zones; thus, the maximum wear score was 126 points.
    The same forty-two inserts were evaluated with regard to wear of the undersurface (so-called backside wear) and evidence of plastic deformation. The inserts were graded according to the method described by Wasielewski et al.16,17, which assesses polyethylene cold flow into the screw-holes on the tibial component (Fig. 3). Five grades of wear were possible: grade 0 (no screw-hole impression visible), grade 1 (partial screw-hole impression visible), grade 2 (entire perimeter of screw-hole impression visible), grade 3 (palpable screw-hole impression, 0.10 to 0.49 millimeter deep, with abrasive wear completely eliminating the surrounding machine lines), and grade 4 (screw-hole impression at least 0.50 millimeter deep or severe linear abrasive wear due to gross relative motion between the insert and the metal backing). The screw-hole impressions were measured with a digital caliper (Mitutoyo Digimatic Caliper, Kanagawa, Japan) to the nearest 0.01 millimeter. The overall grade was the highest grade of all screw-hole impressions. PCA implants, which have only one central screw-hole for tibial tray stabilization, were subjectively evaluated with regard to undersurface wear by examination of the extent of polishing of machine marks and polyethylene cold flow around the outer edges. Lastly, wear patterns of the inserts that initially failed were compared with those of their replacements that later failed.
    Data were analyzed with use of SPSS for Windows statistical software (version 8.0; SPSS, Chicago, Illinois). Fisher's exact test was used to detect significant differences with regard to osteolysis, gender, and implant fixation between the group in which the exchange failed and the group in which the exchange was successful. The nonparametric Mann-Whitney U test was used to compare the two groups with regard to the average patient height, the overall wear score, the delamination score, and the tibiofemoral angle. Kaplan-Meier analysis with log-rank testing was used to examine the survivorship of the replacement inserts in knees that had had the index procedure because of polyethylene wear and that of the inserts in knees that had had the procedure because of failure of a metal-backed patellar component.
    Isolated exchange of the tibial polyethylene insert failed in eight (17 percent) of the forty-eight knees at an average of fifty-four months (range, fifteen to ninety-six months). All eight knees subsequently were treated with total knee revision. The exchange failed in six (27 percent) of the twenty-two knees in which the index procedure had been performed because of accelerated polyethylene wear; all six failures were due to advanced wear of the revision insert after an average of fifty-four months (range, thirty-seven to ninety-six months) in situ. The exchange failed in one (5 percent) of the twenty-one knees in which the index procedure had been performed because of the failure of a metal-backed patellar component; this knee had a repeat revision ninety-two months after the index procedure because of wear of the revision insert and osteolysis. Therefore, seven of the eight failures were due to rapid wear of the new insert. The eighth failure occurred, fifteen months after the insert exchange, because of recurrent rotational instability and secondary patellofemoral subluxation. This patient was excluded from further analyses because the failure was unrelated to polyethylene wear.
    Kaplan-Meier survivorship analysis revealed that at six years the probability of survival of the insert was 100 percent after insert exchanges that had been performed because of the failure of a metal-backed patellar component. After procedures that had been performed because of polyethylene wear, survival was only 64 percent. This difference was significant (p < 0.05, log-rank test) (Fig. 4).
    Forty knees (83 percent) did not require an additional operation after the insert exchange. At the time of the most recent follow-up examination, performed at an average of eighty-six months (range, thirty-five to 146 months), these forty knees had an average flexion contracture of 1.6 degrees (range, 0 to 20 degrees) and an average flexion arc of 110 degrees (range, 60 to 135 degrees). Thirty-six knees had a good or excellent clinical score according to the classification system of the Knee Society8 or that of The Hospital for Special Surgery7. Three of the remaining four knees had a fair score because of limited function with advanced age and generalized arthritis. The fourth knee continued to have a poor knee score and a very limited range of motion (from a 20-degree flexion contracture to 60 degrees of flexion) after insert exchange and excision of scar tissue for severe fibrous ankylosis.

    Factors Associated with Failure of the Exchange

    Six of the seven patients who subsequently required a total knee revision because of polyethylene wear were male. The patients who had a failed exchange were taller than those who had a successful exchange (average height, 178 compared with 160 centimeters; p = 0.057), and they were marginally younger at the time of the index procedure (average age, sixty-four compared with sixty-eight years; p > 0.05). Insert failure was not related to implant design.
    We also examined the relationship between evidence of metallosis at the time of the index procedure and subsequent failure of the exchange. Metallosis was observed in five knees in which a PCA insert was exchanged because of full-thickness wear-through to the tibial base-plate. The retained cobalt-chromium femoral components had slight visible scratching and no visible burnishing. In three of the five knees, the revision insert had accelerated wear and a wear pattern that was similar to that of the original insert. The twenty-one knees that had gross metallosis due to a failed metal-backed patellar component had mild scratching of the femoral component in the region of the patellar groove. However, in this group of twenty-one knees, no association was found between gross metallosis and failure. Similarly, no such association was found in the group of four knees that had metallosis due to impingement of the intercondylar eminence. Overall, only one knee that had metallosis for a reason other than full-thickness wear of the insert required an additional operation after the insert exchange.

    Articular Surface and Undersurface Wear

    The forty-two primary inserts that were examined with regard to region and mode of articular surface wear had an average wear score of 21 points (range, 2 to 43 points) of a possible 126 points. The average wear score for the primary inserts in knees in which the exchange failed was 25 points (range, 8 to 38 points), which was slightly higher than the wear score for the primary inserts in knees in which the exchange was successful (21 points; range, 10 to 43 points) (p = 0.22).
    The average delamination score for all forty-two primary inserts was 7 points (range, 0 to 17 points) of a possible 18 points. The average delamination score for the primary inserts in knees in which the exchange failed (12 points) was significantly higher than that for the primary inserts in knees in which the exchange was successful (7 points) (p < 0.05). The average delamination score for the five inserts in knees that were revised for a reason other than polyethylene wear or failure of a metal-backed patellar component was only 1 point (0, 1, or 2 points).
    Most of the primary inserts had undersurface wear at the time of the exchange procedure. Specifically, thirty-five (83 percent) of the forty-two primary inserts had grade-3 or 4 wear and seven had grade-0, 1, or 2 wear. No significant difference in the undersurface wear of the primary insert could be detected between the knees in which the exchange failed and those in which it was successful; however, none of the seven knees in which the primary insert had grade-0, 1, or 2 wear went on to have failure of the revision insert.
    When the primary inserts that failed were compared in a visual manner with their replacements that subsequently failed, the two inserts in each pair usually revealed similar wear patterns. Six matched pairs of inserts were available for comparison. Five pairs were from knees in which both the primary and the revision insert failed because of accelerated wear. This group included two pairs in which the two inserts had symmetrical wear patterns, two pairs in which the two inserts had identical medial wear patterns, and one pair in which the two inserts had matching lateral wear patterns. The sixth matched pair was from a knee that initially was revised because of the failure of a metal-backed patellar component and subsequently was revised because of severe wear and osteolysis. In this pair, the initial insert had symmetrical wear but the revised insert had mostly medial wear.

    Radiographic Findings

    The average tibiofemoral angle was 4 degrees of valgus (range, 1 to 6 degrees of valgus) in the seven knees in which the exchange failed and 6 degrees of valgus (range, 1 to 13 degrees of valgus) in the forty knees in which the exchange was successful. The tibiofemoral angle was between 1 and 10 degrees of valgus for all but two of the forty-seven knees. Both of the malaligned knees, which had tibiofemoral angles of 12 and 13 degrees of valgus, had a successful insert exchange.
    In the seven knees in which the exchange failed, the average angle between the tibial component and the tibial axis was 2 degrees of varus (1, 2, or 3 degrees of varus) and the average angle between the femoral component and the femoral axis was 6 degrees of valgus (5, 6, or 7 degrees of valgus). In the forty knees in which the exchange was successful, the average angle between the tibial component and the tibial axis was 1 degree of varus (range, 4 degrees of varus to 1 degree of valgus) and the average angle between the femoral component and the femoral axis was 8 degrees of valgus (range, 3 to 13 degrees of valgus).
    Nineteen knees had osteolytic lesions at the time of the insert exchange. Only one of these knees had a complication secondary to the osteolysis. Fourteen of the nineteen knees had a successful insert exchange, with no evidence of osteolytic progression. The other five knees had failure of the exchange. In two of these five knees, the osteolytic defects healed after being treated with morseled allograft bone at the time of total knee revision. In another two knees, the osteolytic lesions showed no evidence of progression after treatment with curettage. The fifth knee, which received one of the four Hylamer-M inserts at the time of the exchange, had progressive femoral osteolysis. This patient sustained a supracondylar fracture that necessitated two femoral head allografts with total knee revision.
    The rates of polyethylene wear and osteolysis - increasingly common mechanisms of failure in patients who have had a total knee arthroplasty2-5,9,11,14,15 - have been on the rise since the advent of modular knee designs, as evidenced by the paucity of clinical case reports published before 199213. It is clear that revision arthroplasty is necessary when the tibial and femoral components are loose, but the solution is not as obvious when the tibial and femoral components are well fixed and the polyethylene fails. The surgeon must decide when it is appropriate to revise stable tibial or femoral components and when it is appropriate to simply exchange the polyethylene insert.
    The findings of this report begin to clarify the indications for polyethylene insert exchange with retention of the femoral and tibial components. Our results suggest that polyethylene insert exchange should not be performed when the primary insert has (1) severe wear within ten years after insertion, (2) severe delamination, (3) full-thickness wear-through, or (4) extensive backside wear. However, because this study included a limited number of knees (forty-eight) and a small number of failed exchanges (eight), additional studies are necessary to confirm these impressions.
    Wear of a modular polyethylene tibial insert is influenced by a combination of implant characteristics (polyethylene thickness, type of locking mechanism, and design and finish of the bearing surfaces) and patient-related factors (age, weight, height, activity level, length of time with the implant in situ, and component alignment). Insert exchange can address only some of the implant features that contribute to accelerated polyethylene wear. New inserts could be thicker5, manufactured from machined or molded polyethylene instead of heat-pressed material, or sterilized without use of gamma radiation in air; however, surgeons must determine whether changing such variables would reduce wear or if other variables (such as micromotion of the tibial tray, ligamentous balance, third-body wear, and damaged or poorly functioning locking mechanisms) still would make the results of insert exchange unpredictable.
    The assessment of the failed primary inserts provided insight into the polyethylene wear characteristics that predispose an insert exchange to failure. The inserts that were removed from knees in which the exchange subsequently failed had notable backside wear and higher delamination scores than those that were removed from knees in which the exchange was successful, suggesting that surgeons should assess delamination of the articulating surface and backside wear of the polyethylene insert when considering an isolated insert exchange. Wasielewski et al.17 identified backside wear as a major source of polyethylene debris contributing to tibial osteolysis. Just as a damaged or flawed locking mechanism permits micromotion and subsequent wear, micromotion of an insert against an unpolished tibial tray (as occurred in the report by Wasielewski et al. and the present series) accelerates wear. The potential for substantial micromotion of the tibial insert has been reported in association with a variety of snap-fit and tongue-in-groove tibial tray capture mechanisms12.
    So-called counterface roughness of the femoral component also greatly influences polyethylene wear2. Scratches on the femoral component increase surface roughness and accelerate the wear of the polyethylene insert. Dwyer et al.2 found that retrieved femoral components that had been revised in association with severe polyethylene wear had significantly greater surface roughness than control components that had not been implanted (p < 0.005). With use of scanning electron microscopy, Dwyer et al. detected scratches, grooves, and particulate matter within the surface defects of the retrieved components. However, it remains unclear how much damage necessitates a complete revision of a well fixed femoral component to avoid the accelerated wear that is associated with the retention of a damaged component.
    Femoral components that have metal-on-metal contact because of full-thickness wear-through of the insert are of special concern. In the present study, three of five knees that were revised in the presence of full-thickness wear-through of the primary insert had subsequent failure of the revision insert. Our experience has indicated that when a femoral component has articulated with a metal tibial base-plate it is likely that the component is damaged and that the new insert will have accelerated wear. In contrast, Knight et al.10 reported no adverse effects after retention of eleven femoral components that were associated with full-thickness wear-through and seven femoral components that had burnishing because of metal-on-metal contact. However, the short duration of follow-up in that study (average, twenty-four months; range, five to thirty-six months) prevents definitive conclusions from being drawn.
    The presence of metallosis in association with a failed metal-backed patellar component would seem to necessitate total knee revision. Prior to insert revision, more than 50 percent (twenty-six) of the forty-eight knees in the present study had extensive metallosis with the inherent potential for abrasive third-body wear. The most frequent sources of metal debris in these knees were a failed metal-backed patellar component (twenty-one knees) and metal-on-metal contact of the femoral and tibial components (five knees). Most of the knees were treated with insert exchange combined with revision of the metal-backed patellar component, and only one knee subsequently had failure of the revision insert. Additional studies are needed to refine the indications and contraindications for retaining components that have been exposed to third-body debris.
    The most noteworthy patient-related factors associated with accelerated implant wear in this study were gender and height. Six of the seven insert exchanges that failed because of insert wear were in male patients. Heck et al.5 reported a preponderance of male patients in their study of twelve knees with gross polyethylene failure. Those authors also found that patients who had polyethylene failure were significantly taller than those who did not (average height, 176 compared with 161 centimeters; p = 0.003); this finding was duplicated in our study (p = 0.057). These findings may be evidence of the association between the variables of gender and height.
    Abnormal loading patterns also can contribute to increased rates of polyethylene wear. For instance, if the knee remains malaligned and imbalanced, the revision insert will be subjected to the same forces that contributed to the accelerated wear of the primary insert. In our study, five of the six matched pairs displayed similar wear patterns on both the primary and the revision insert.
    As an alternative to complete revision in knees that have reasonable but suboptimal alignment in the presence of well fixed components, Shaw14 suggested revising the polyethylene insert with one that is thicker on the undercorrected side of the deformity. It is possible that this option could reduce wear by correcting alignment and thereby changing the kinematics and stresses on the polyethylene insert. Larger sample sizes and longer-term follow-up are needed to validate the efficacy of such custom bearings.
    An important factor in predicting the success of a revision insert seems to be the length of time that the primary insert performed acceptably before failing. A replacement insert likely will perform well for a reasonable period if the initial insert did the same. We concluded that insert exchange with retention of the tibial and femoral components may be appropriate when the primary insert has had acceptable wear performance. We therefore believe simple insert exchange is indicated for patients who have late failure of the primary tibial insert. We also revise inserts that have mild-to-moderate wear when knee surgery is being performed for other reasons.
    Conversely, a replacement insert is likely to show wear within a relatively short time if the initial insert failed rapidly. We are reluctant to perform an isolated insert exchange for patients who have polyethylene wear (particularly delamination) within a relatively short time, have full-thickness wear of the insert, or have advanced undersurface wear of the insert or damage to the tibial base-plate (both of which are suggestive of design-specific problems with the locking mechanism of the tibial tray). On occasion, we perform an isolated insert exchange for an elderly, low-demand patient in order to avoid a more complex procedure involving revision of well fixed tibial and femoral components. However, whenever a damaged femoral component is retained or a potentially poor modular tibial locking mechanism is present with resultant backside wear, increased clinical and radiographic surveillance is necessary in order to identify extensive polyethylene wear and osteolysis.
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    Tsao, A.; Mintz, L.; McRae, C. R.; Stulberg, S. D.; and Wright, T.: Failure of the porous-coated anatomic prostheses in total knee arthroplasty due to severe polyethylene wear. J Bone Joint Surg,75-A: 19-26, Jan. 1993.75-A19  1993 
     
    Wasielewski, R. C.; Galante, J. O.; Leighty, R. M.; Natarajan, R. N.; and Rosenberg, A. G.: Wear patterns on retrieved polyethylene tibial inserts and their relationship to technical considerations during total knee arthroplasty. Clin. Orthop.,229: 31-43, 1994.22931  1994 
     
    Wasielewski, R. C.; Parks, N.; Williams, I.; Surprenant, H.; Collier, J. P.; and Engh, G.: Tibial insert undersurface as a contributing source of polyethylene wear debris. Clin. Orthop.,345: 53-59, 1997.34553  1997  [PubMed]
     

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    Anchor for JumpAnchor for Jump
    +Fig. 1:Photograph of one of the twenty-two inserts that were exchanged because of advanced polyethylene wear, showing extreme delamination of the articular surface and fracture of the polyethylene.
    Anchor for JumpAnchor for Jump
    +Fig. 2:Photograph of one of the twenty-one worn inserts (left) that were exchanged in conjunction with revision of a failed metal-backed patellar component (right).
    Anchor for JumpAnchor for Jump
    +Fig. 3:Photograph of a tibial base-plate (top) and the undersurface of the tibial insert (bottom), showing classic wear-polishing indicated by stippling patterns and metal burnishing. Polyethylene cold flow into the screw-holes and the margins of the tibial tray are indicated by arrows.
    Anchor for JumpAnchor for Jump
    +Fig. 4:Kaplan-Meier survivorship curves for the replacement inserts in knees that had been revised because of the failure of a metal-backed patellar component (Group 1) and for those that had been revised because of polyethylene wear (Group 2). The thin brackets designate the standard error for each curve.
    Bugbee, W. D.; Ammeen, D. S.; Parks, N. L.; and Engh, G. A.: 4- to 10-year results with the anatomic modular total knee. Clin. Orthop.,348: 158-165, 1998.348158  1998  [PubMed]
     
    Dwyer, K. A.; Topoleski, L. D. T.; Bauk, D. J.; Nakielny, R.; and Engh, G. A.: The neglected side of the wear couple: analysis of surface morphology of retrieved femoral components. Trans. Orthop. Res. Soc.,18: 82, 1993.1882  1993 
     
    Engh, G. A.; Dwyer, K. A.; and Hanes, C. K.: Polyethylene wear of metal-backed tibial components in total and unicompartmental knee prostheses. J Bone Joint Surg,74-B(1): 9-17, 1992.74-B(1)9  1992 
     
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    Heck, D. A.; Clingman, J. K.; and Kettelkamp, D. G.: Gross polyethylene failure in total knee arthroplasty. Orthopedics,15: 23-28, 1992.1523  1992  [PubMed]
     
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    Insall, J. N.; Ranawat, C. S.; Aglietti, P.; and Shine, J.: A comparison of four models of total knee replacement prostheses. J Bone Joint Surg,58-A: 754-765, Sept. 1976.58-A754  1976 
     
    Insall, J. N.; Dorr, L. D.; Scott, R. D.; and Scott, W. N.: Rationale of the Knee Society clinical rating system. Clin. Orthop.,248: 13-14, 1989.24813  1989  [PubMed]
     
    Jones, S. M. G.; Pinder, I. M.; Moran, C. G.; and Malcolm, A. J.: Polyethylene wear in uncemented knee replacements. J Bone Joint Surg,74-B(1): 18-22, 1992.74-B(1)18  1992 
     
    Knight, J. L.; Gorai, P. A.; Atwater, R. D.; and Grothaus, L.: Tibial polyethylene failure after primary porous-coated anatomic total knee arthroplasty. Aids to diagnosis and revision. J. Arthroplasty,10: 748-757, 1995.10748  1995  [PubMed]
     
    Lewis, P.; Rorabeck, C. H.; Bourne, R. B.; and Devane, P.: Posteromedial tibial polyethylene failure in total knee replacements. Clin. Orthop.,299: 11-17, 1994.29911  1994  [PubMed]
     
    Parks, N. L.; Engh, G. A.; Topoleski, L. D. T.; and Emperado, J.: Modular tibial insert micromotion. A concern with contemporary knee implants. Clin. Orthop.,356: 10-15, 1998.35610  1998  [PubMed]
     
    Peters, P. C., Jr.; Engh, G. A.; Dwyer, K. A.; and Vinh, T. N.: Osteolysis after total knee arthroplasty without cement. J Bone Joint Surg,74-A: 864-876, July 1992.74-A864  1992 
     
    Shaw, J. A.: Angled bearing inserts in total knee arthroplasty. A brief technical note. J. Arthroplasty,7: 211-216, 1992.7211  1992  [PubMed]
     
    Tsao, A.; Mintz, L.; McRae, C. R.; Stulberg, S. D.; and Wright, T.: Failure of the porous-coated anatomic prostheses in total knee arthroplasty due to severe polyethylene wear. J Bone Joint Surg,75-A: 19-26, Jan. 1993.75-A19  1993 
     
    Wasielewski, R. C.; Galante, J. O.; Leighty, R. M.; Natarajan, R. N.; and Rosenberg, A. G.: Wear patterns on retrieved polyethylene tibial inserts and their relationship to technical considerations during total knee arthroplasty. Clin. Orthop.,229: 31-43, 1994.22931  1994 
     
    Wasielewski, R. C.; Parks, N.; Williams, I.; Surprenant, H.; Collier, J. P.; and Engh, G.: Tibial insert undersurface as a contributing source of polyethylene wear debris. Clin. Orthop.,345: 53-59, 1997.34553  1997  [PubMed]
     
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