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The Orthopaedic Forum   |    
The Orthopaedic Clinician-Scientist
Douglas W. Jackson, MD
The Journal of Bone & Joint Surgery.  2001; 83:131-131 
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Most applicants for orthopaedic residencies and fellowships state that they wish to do some teaching and research when they finish their training. However, this initial interest in research is not sufficiently maintained to replenish the pool of clinician-scientists in orthopaedics. This problem is not unique to our field; clinician-scientists are an endangered species in many other specialties as well. From 1994 to 1997, the actual number of all first-time physician applicants for National Institutes of Health research grants plummeted 31%. If this progression were to continue linearly, there would be no first-time physician applicants by 20031. While support from the National Institutes of Health is not the only way to sustain a research career, it is a bellwether of clinician-scientists doing work at that recognized high level. James Wyngaarden, former director of the National Institutes of Health, called attention to this developing trend in 1979 in an article entitled "The Clinical Investigator as an Endangered Species."2 This progressive shift away from scientific investigation and toward large clinical series and case reports has been noted by others3. Francis Moore, in 1976, spoke of the unresolved conflict "between the operating room and the laboratory . . . between the clinical pressures of care of the sick and the pursuit of science."4 Many people in the research community believe that the small number of orthopaedic clinician-scientists capable of doing rigorous and meaningful research is the result of increasing conflict within the system5. Time and financial considerations are the major reasons for the diminishing numbers of clinician-applicants who are competing successfully for major federal funding.
We all should recognize the need in our specialty for a cadre of orthopaedic clinician-scientists involved in basic, disease-oriented, patient-oriented, and prevention-oriented research. These unique individuals are necessary to create a bridge from the laboratory to the bedside. They pose the relevant clinical questions that form the basis of specific investigations leading to clinically relevant, effective, and safe solutions. Besides bringing clinical relevance to future musculoskeletal research, these clinically oriented researchers will be some of our profession's most valued teachers as well as the authors of educational material for orthopaedic surgeons and students. They will raise the bar and set the new standards for research in our specialty. It is likely that the loss of the orthopaedic clinician-scientist will ultimately have a negative impact on advances in our field and will limit our ability to promote the health of our patient population to the maximum.
The commitment to learning clinical skills occupies the time of bright young minds in orthopaedics during residency training. After the completion of clinical, surgical, and emergency-coverage duties, little time is left for young clinicians to acquire the research skills necessary to be competitive with full-time scientists for grants. Usually, the clinician must spend an additional two to three years in specialized research training to obtain the knowledge, skills, and experience that are necessary in order to be competitive for national peer-reviewed funding. The optimal timing for the acquisition of the needed research training is debatable and must be individualized. Ideally, individuals can make the best choice for their research career after they have a perspective on the field of orthopaedics and have insight into specific clinically related issues that need to be addressed. Even residents who have a PhD degree prior to residency training have difficulty maintaining and staying current in their scientific discipline during their surgical residency. At the conclusion of their residency training, they often find that they have fallen behind in the rapidly evolving scientific community or that their interests lead them to become full-time clinicians.
The other major consideration that deters young clinicians from pursuing a career as a clinician-scientist is financial. This is often related to the debt that has accumulated during years of training and to individuals' desire to start earning an income that will provide for themselves and their families. In addition, young orthopaedic surgeons feel peer pressure to excel in the clinical arena and want to be known for having "good hands" and for "carrying their weight" in the clinical care of patients. Spending time in research often conflicts with these other objectives4. Our current system produces more than 600 new orthopaedic surgeons each year. Recent workforce studies indicate that we are producing more than enough clinicians, but at the same time we are not replenishing the critical pool of clinician-scientists6. At the end of their surgical training, these individuals are good clinicians but are not sufficiently prepared in scientific methodologies to be competitive for federal or private research funding.
Several important questions regarding the future of the orthopaedic clinician-scientist must be addressed.

Question: What are some of the common deterrents to the young orthopaedic surgeon becoming a clinician-scientist?

1. There is a lack of successful mentors and available role models to stimulate potential young investigators in our field.
2. There is a widely held perception that basic and in-depth research is the purview of the PhD scientist and that the orthopaedic surgeon does not or cannot play a role in this type of research.
3. The infrastructure of most institutions does not provide a nurturing and supportive environment for a research career in orthopaedics.
4. There is a lack of definition, scope, and perceived security in this potential career path.
5. There is no existing structure within orthopaedics that can bridge the organizations capable of reducing the impediments to the choice of research as a career track.
6. The significant educational debt burden of becoming an orthopaedic surgeon discourages many from pursuing the research career track. Such a career choice currently prolongs debt repayment and may actually introduce more debt.
7. Young surgeons in their early thirties, after years of training and with increasing family and financial responsibilities, appear more driven toward enhancing their potential income than toward spending additional time in research.
8. Institutional emphasis on and support for primary care and generalization (less subspecialization) during medical school entices potential clinician-scientists into nonsurgical research careers prior to their exposure to orthopaedics.
9. There is a lack of adequate financial support for additional education and training in research following the residency and fellowship years.
10. There is peer pressure from orthopaedic colleagues to participate in the sharing of clinical responsibilities. Surgeons often gain the most recognition and satisfaction from working in a busy surgical practice. Consequently, less time is spent pursuing in-depth clinical research.

Question: How much research time is necessary to be competitive for federal grants?

There are exceptions; however, it would appear that a successful clinician-scientist needs a minimum
of two days of protected time per week or an equivalent time allocation per year. The process of becoming a principal or co-investigator on a major grant is quite competitive. Most individuals receiving major research grants hold full-time research positions and spend more than two days per week committed to their research efforts. The orthopaedic clinician-scientist faces two challenges: (1) obtaining recognition from the scientific community as a peer, and (2) obtaining recognition from full-time clinicians that their research (and the time that it requires) is important to the field of orthopaedics and to the patients whom we serve. It is difficult to be competitive for grant support when less than two days per week are devoted to research. At the same time, it is difficult to remain clinically effective when less than three days per week are devoted to one's practice. This is the dichotomy of being a clinician-scientist. The maintenance of clinical relevance and surgical skills takes time and commitment, as does scientific research. Orthopaedic clinician-scientists sometimes feel alienated from both the scientific community and their surgical colleagues because of the disparate expectations and standards of the two communities. Adequate protected time, the right basic-science and/or research team, and the proper institutional infrastructure are essential in order for the clinician-scientist to reach his or her full potential.

Question: How much should a young orthopaedic surgeon pursuing a career as a clinician-scientist expect to earn per year?

The clinician-scientist must realize that his or her income will be less than that of a full-time clinician working within an orthopaedic department. Nonmonetary rewards and support as well as intellectual satisfaction should be as important to the potential clinician-scientist as income is. Other critical considerations are the availability of laboratory space, protected time, technicians, assistants, and mentoring. The starting income for a young orthopaedic clinician-scientist with two days of protected time per week is currently less than that of a full-time clinician. Ideally, it should be the total of two-fifths of a full-time research scientist's salary plus three-fifths of a young clinician's compensation, reflecting the individual's participation in the department's practice plan.
A major financial obstacle that the clinician-scientist often faces is the overhead costs of maintaining his or her clinical practice, particularly during protected research time. If the department's practice plan is providing overhead support, it takes several full-time clinicians in the department to cover the overhead and to provide the clinical support that will allow the clinician-scientist to have the equivalent of two protected days per week. Outside sources of funding, such as endowments or institutional funds, also can ease this financial burden and can help the individual to maintain protected time. Currently, just a few orthopaedic training programs are effectively addressing the issue of protected research time.

Question: How many career orthopaedic clinician-scientists conducting research that is competitive for federal grants can we hope to see emerge in the United States each year?

Because the orthopaedic clinician-scientist is an endangered species, the goal should be for at least three to six new individuals to enter and remain in the field each year. A yearly addition of three to six new individuals who are committed to a twenty to thirty-year research career would infuse our specialty with a valuable resource. Recruitment, mentoring, and support are needed in order to obtain this commitment. Substantial financial support is needed initially, and in many cases it may be required for up to seven years to ensure the transition to self-support through grants. Currently, there may be only ten to twenty institutions with the resources, the "team," and the desire to recognize and nurture clinician-scientists.

Question: What will happen if organized orthopaedics does nothing more and waits for outside solutions?

The current marketplace and the funding mechanisms for resident training are a deterrent to the development of orthopaedic clinician-scientists within the existing programs and structure. However, certain changes might evolve over time outside of orthopaedics.
1. More federal funds and other debt-reduction programs will be developed in areas of the greatest perceived research need.
2. Individuals currently receiving federal funding for PhD/MD programs tend to commit to their PhD research before they consider a field requiring an additional five years of surgical training. They also tend to be recruited or attracted to nonsurgical fields. Funding might be restructured to encourage more individuals to select a musculoskeletal research career after their orthopaedic training.
3. Eventually, the forces of supply and demand may diminish the income discrepancies currently experienced by clinician-scientists compared with full-time clinicians.
4. Individuals with a PhD degree may continue to assume a greater portion of the research effort in orthopaedics.
5. Outside foundations and/or industry may fund or develop specific programs to address the needs of potential clinician-scientists.
6. If orthopaedic clinician-scientists become extinct, other scientists will assume the role of assessing orthopaedic treatments, indications, and outcomes. They also will oversee and evaluate prevention and disease-management programs in our field. This trend is already developing.

Question: What are the common ingredients of programs that produce successful clinician-scientists?

1. The availability of and access to role models, mentors, and colleagues within and outside of the training institution. (This component is critically important.)
2. A research infrastructure that encourages and facilitates opportunities for collaborative and co-investigative multifaceted analysis and research projects.
3. Sufficient institutional funding sources to support an established, ongoing research program. In most cases, significant funding comes from the orthopaedic and/or surgical department and the institution, and additional funding comes from private and public sources.
4. An institutional infrastructure (core facilities, research libraries, and readily available research assistants) that supports research.
5. Sufficient protected time to conduct research on a consistent basis. (This component is a high priority.)
6. Rewards for a productive research program.
7. A process for attracting and selecting promising residents, in the hope that they will become successful researchers.
8. Institutional access to relevant clinical patient populations.

Strategies for the Orthopaedic Community to Impact the Number of Future Clinician-Scientists in Our Specialty

1. We should build and expand on our current strengths.
(a) Currently, there is a talented pool of individuals in our orthopaedic training programs who have the potential to become clinician-scientists. This pool should be tapped.
(b) We should expand, formalize, and monitor our current mentoring efforts.
(c) We should recognize current orthopaedic clinician-scientist role models and expose young clinicians to them.
(d) We should support and encourage the ten to twenty programs with the basic and clinical-research infrastructure capable of developing more orthopaedic clinician-scientists.
(e) We should parlay, expand, and additionally fund the excellent progress that the Orthopaedic Research and Education Foundation has demonstrated in addressing the issues facing the young investigator. As a specialty, we are fortunate to have in place a research and education foundation with such a strong record of accomplishment. This demonstrates the vision of past leadership to address the issue. However, times have changed, and the effort needs to be increased. The Orthopaedic Research and Education Foundation is an excellent platform on which we can continue to build.
(f) A portion (1% to 2%) of the financial reserves of the American Academy of Orthopaedic Surgeons could be used to match funds for bold and innovative pilot efforts to develop orthopaedic clinician-scientists. This is simply "R and D" money that would help to maximize our specialty's potential to deliver the highest-quality patient care and outcomes.
2. The leadership of the influential orthopaedic organizations that compose the "House of Orthopaedics" must make a bold and concerted effort if we wish to maintain orthopaedic clinician-scientists within our specialty. This will require restructuring or creating an independent structure within orthopaedics that is able to cross organizational lines and coordinate all of the organizations that can contribute to reducing the obstacles to this career choice. No single existing organization can independently change the current trends. Representatives from the organizations capable of making an impact must come together to stimulate, support, and monitor the development of orthopaedic clinician-scientists. To ensure a sustainable effort, adequate funding will be needed. The core of this funding must come from the profession of orthopaedics. Once we have established a methodology and have demonstrated our resolve with a major financial commitment, we can pursue supplemental matching funds from federal, private, and industrial sources.
3. Strategies for coalition-building must be identified, impl
emented, and monitored.(a) We should expand participation in current coalition efforts for training and research funding in cooperation with the National Institutes of Health and other federal and private funding sources. (Our specialty is currently represented in such organizations as the National Institute of Arthritis and Musculoskeletal and Skin Diseases Coalition, the Friends of the Department of Veterans Affairs, and the Ad Hoc Group for Medical Research Funding.)
(b) We should identify health-policy initiatives, which are shared with a variety of patient and physician groups, to encourage the forging of new partnerships in the health-policy and funding arena in order to address the problem of the endangered clinician-scientist.
(c) We should use the opportunity provided by "The Bone and Joint Decade" to stress the burden of musculoskeletal diseases and the prevalence of these conditions in the United States. We also should publicize the need for clinician-scientists to address these major diseases and conditions in order to enhance quality of life.
4. Orthopaedic leaders should articulate the need for, and work toward, the development of a cadre of clinician-scientists in musculoskeletal research.
5. Pilot studies should be undertaken with research-oriented individuals in specific orthopaedic training programs that have demonstrated the potential to produce orthopaedic clinician-scientists. This will mean additional support for institutions that have demonstrated success in their existing programs.
6. Innovative research training tracks should be developed within orthopaedics. This may mean interruptions for a few years during clinical training for a select few, credit for some of the years of additional scientific training during residency, or possible geographic displacement during residency or fellowship in order to acquire specific training.
7. The efforts of organized orthopaedics should be expanded to support clinician-scientists at each level of their career (particularly at entry level and at midlevel) by promoting sources of funding, identifying debt-reduction programs, and recognizing the value of these individuals to orthopaedics.
8. Mentoring programs should be further formalized and expanded to encourage the development of orthopaedic clinician-scientists.
9. Medical schools should be actively supported in encouraging individuals to pursue research careers as clinician-scientists.
Note: The author especially wishes to acknowledge the Orthopaedic Clinician-Scientist Steering Committee and workshop panel as follows: Gunnar Andersson, MD, PhD, Scott Boden, MD, Adele Boskey, PhD, Richard Brand, MD, Joseph Buckwalter, MD, Richard Coutts, MD, Thomas Einhorn, MD, Michael Ehrlich, MD, Gary Friedlaender, MD, Mark Gebhardt, MD, Michael Goldberg, MD, Steve Goldstein, PhD, Stuart Goodman, MD, Douglas Jackson, MD, Joshua Jacobs, MD, Jim Panagis, MD, Larry Rosenthal, PhD, Randy Rosier, MD, PhD, Peter Rou ghley, PhD, Linda Sandell, PhD, and Russell Warren, MD.
Rosenberg L: Physician-scientists-endangered and essential. Science.,1999.283: 331-2, 283331  1999  [PubMed]
 
Wyngaarden JB: The clinical investigator as an endangered species.. N Engl J Med. ,1979.301: 1254-9, 3011254  1979  [PubMed]
 
Gill G: The end of the physician scientist?. Am Scholar.,1984.53: 353-68, 53353  1984 
 
Folkman J: Surgical research: a contradiction in terms?. J Surg Res. ,1984.36: 294-9, 36294  1984  [PubMed]
 
Hurwitz SR, and Buckwalter JA: The orthopaedic surgeon scientist: an endangered species? [editorial].. J Orthop Res. ,1999.17: 155-6, 17155  1999  [PubMed]
 
Lee PP; Jackson CA; and Relles DA: Demand-based assessment of workforce requirements for orthopaedic services. J Bone Joint Surg Am.,1998.80: 313-26, 80313  1998  [PubMed]
 

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Topics

Rosenberg L: Physician-scientists-endangered and essential. Science.,1999.283: 331-2, 283331  1999  [PubMed]
 
Wyngaarden JB: The clinical investigator as an endangered species.. N Engl J Med. ,1979.301: 1254-9, 3011254  1979  [PubMed]
 
Gill G: The end of the physician scientist?. Am Scholar.,1984.53: 353-68, 53353  1984 
 
Folkman J: Surgical research: a contradiction in terms?. J Surg Res. ,1984.36: 294-9, 36294  1984  [PubMed]
 
Hurwitz SR, and Buckwalter JA: The orthopaedic surgeon scientist: an endangered species? [editorial].. J Orthop Res. ,1999.17: 155-6, 17155  1999  [PubMed]
 
Lee PP; Jackson CA; and Relles DA: Demand-based assessment of workforce requirements for orthopaedic services. J Bone Joint Surg Am.,1998.80: 313-26, 80313  1998  [PubMed]
 
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Jaimo Ahn
Posted on September 10, 2001
For a future rich with orthopaedic clinician-scientists, invest now in CDs
University of Pennsylvania

To The Editor,

As a senior MD-PhD (combined degree or CD) student heading toward a career as an orthopaedic clinician-scientist, I took great interest in the article "The Orthopaedic Clinician-Scientist" (83-A: 131-135, Jan. 2001) by former President of the AAOS, Dr. Douglas Jackson. I was impressed with the scope of suggestions provided by Dr. Jackson as well as the emphasis that this article and others have recently placed on the task of enlarging a shrinking community of clinician-scientists in orthopaedic surgery specifically1-3 and in medicine in general4. I agree with Dr. Jackson that steps must be taken to reduce barriers and provide incentives at various stages of an academic career. I would like to specifically emphasize the need for early intervention and support (while still in training) in the nurturing of burgeoning orthopaedic clinician-scientists.

This emphasis is especially crucial in light of a recent report that suggests a minimal potential for contributions by MD-PhD training programs to academic orthopaedics5. As the study of past MSTP participants indicates, a disproportionately small percentage of graduates of such programs go on to academic orthopaedic careers and, therefore, constitute only a small percentage of currently active clinician-scientists in orthopaedic surgery. In this instance, however, the lack of past contributions should not be used as a predictor of future outcome.

The contribution of early influences and education in fostering future orthopaedic-scientists—or any particular path for that matter—should not be underestimated. A proactive and multifaceted approach (as Dr. Jackson suggests) that includes identification and mentoring of undergraduate medical students (especially MD-PhDs) is needed. The impact will be especially pronounced precisely because the clinician-scientist is rare. Even a small number of faculty members at each institution can carry an amplified voice in the relative void of information. Students expect an occasional orthopaedic surgeon to be at the gross anatomy table disseminating their knowledge. Imagine the surprise and potential influence of an orthopaedic faculty member offering mentorship at an MD-PhD gathering or retreat. There may be an initial latency, but as outspoken faculty and interested students become more visible, the numbers should dramatically increase.

At the University of Pennsylvania, it is well established that a large proportion of MD-PhD students will apply for residency positions in pathology, pediatrics and medicine6. Those numbers for any given year may vary but in general a large proportion enter into fields that are already well represented or even over-represented with MD-PhDs5. A smattering of students "stray" into other fields. Anecdotally, a few current trends cannot escape notice. There are increasing numbers of MD-PhDs entering into ophthalmology, dermatology and radiation oncology. Why? Lifestyle differences or amount of protected academic time may be issues. An influence that should not be overlooked, however, is the network between students that develops especially in larger combined-degree programs. Students take great notice of the attitudes and perceptions of those more senior and to match lists. A few mentors, a few students, a perception of scientific excitement as well as a genuine interest by residency programs in MD-PhD students will lead to more students, future mentors and a renewing of the cycle.

Conjectures aside, an important question that needs to be addressed in greater depth is why MD-PhD students do not choose orthopaedic surgery. The reality is that students do not directly feel the impact of any barriers but rather function under perceptions oftentimes influenced by hearsay imparted upon them by others. What are those perceptions and what can we do either to change them where possible or to prevent them from being barriers to entry? Are MD-PhD students even aware of the need and desire for more research as espoused by the leadership of the AAOS2,3? Knowing these answers will help guide the field in attracting students from a talented and eager pool of future scientists, clinicians and leaders.

References:

1. Hurwitz, S. R., and Buckwalter, J. A.: The orthopaedic surgeon scientist: an endangered species? J Orthop Res, 17(2): 155-6., 1999. 2. Jackson, D. W.: The orthopaedic clinician-scientist. J Bone Joint Surg Am, 83-A(1): 131-5., 2001. 3. Gelberman, R. H.: The Academy on the edge: taking charge of our future. J Bone Joint Surg Am, 83-A(6): 946-50., 2001. 4. Rosenberg, L.: Physician-scientists--endangered and essential. Science, 283(5400): 331-2., 1999. 5. Clark, J. M., and Hanel, D. P.: The contribution of MD-PhD training to academic orthopaedic faculties. J Orthop Res, 19(4): 505-10., 2001. 6. Schwartz, P., and Gaulton, G. N.: Addressing the needs of basic and clinical research: analysis of graduates of the University of Pennsylvania MD-PhD program. Jama, 281(1): 96-7, 99., 1999.

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