JBJS | Transfer of Paget's Diseasefrom One Part of the Skeleton to Another as a Result of Autogenous Bone-Grafting : A Case Report

The Journal of Bone & Joint Surgery, Volume 84, Issue 11

Case Reports | November 01, 2002

Transfer of Paget's Diseasefrom One Part of the Skeleton to Another as a Result of Autogenous Bone-Grafting : A Case Report

Moussa Hamadouche, MD, PhD; Michel Mathieu, MD; Vicken Topouchian, MD; Gonzague de Pinieux, MD; Jean Pierre Courpied, MD

The Journal of Bone & Joint Surgery. 2002; 84:2056-2061

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Paget's disease of bone is a pathologic condition marked by increased bone resorption and formation ^1,2 . The exact etiology is not fully understood; however, a slow paramyxovirus infection occurring in patients with a genetic predisposition is suspected ³ . The proximal part of the femur and the acetabulum are involved in as many as 80% of patients with Paget's disease ⁴ . Also, osteoarthritis of the hip joint is frequently associated with Paget's disease with medial or concentric wear patterns ⁵ . Four major studies on the efficacy of total hip arthroplasty for the treatment of Paget's disease of the hip have been reported ^6-10 . Complications associated with the procedure have included varus placement of the femoral component, protrusio acetabuli, increased blood loss, difficulty with reaming due to sclerotic bone, heterotopic ossification, and an increased risk of mechanical failure. Recently, extremely rapid osteolysis in the proximal part of the femur was reported following total hip arthroplasty in a patient with extensive Paget's disease of the pelvis and femur ¹¹ .

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Topics

bone transplantation ; femur ; paget's disease, mammary ; osteitis deformans ; hip replacement arthroplasty

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These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.

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