Extract
Bleeding into joints and muscles is a known complication of
hemophilia1,2.
Circulating levels of factor VIII are closely related to the severity and
frequency of the
bleeding3. When the
factor-VIII level is <1%, bleeding can be severe and serious hemarthrosis
occurs. When the level is between 1% and 5%, gross bleeding may occur after
minor trauma. When it is between 5% and 25%, severe bleeding usually occurs
only with trauma or surgery, and when it is between 25% and 50%, bleeding
occurs only after severe
trauma3. Hemophilia
is classified as severe when the factor-VIII level is <1%, moderate when it
is between 1% and 5%, and mild when it is between 5% and
25%4.