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Randomized Comparison of Reduction and Fixation, Bipolar Hemiarthroplasty, and Total Hip ArthroplastyTreatment of Displaced Intracapsular Hip Fractures in Healthy Older Patients
J.F. Keating, FRCSEd(Orth)1; A. Grant, DM2; M. Masson, MSc3; N.W. Scott, MSc4; J.F. Forbes, PhD5
1 Department of Orthopaedic Trauma, Royal Infirmary, Little France, Old Dalkeith Road, Edinburgh EH16 4SU, Scotland. E-mail address: john.keating@ed.ac.uk
2 Health Services Research Unit, University of Aberdeen, Aberdeen AB25 2ZD, Scotland
3 Royal Infirmary of Edinburgh, Edinburgh EH16 4SU, Scotland
4 Department of Public Health, University of Aberdeen, Aberdeen AB25 2ZD, Scotland
5 School of Clinical Sciences and Community Health, University of Edinburgh, Teviot Place, Edinburgh EH9 9AG, Scotland
The Journal of Bone & Joint Surgery.  2006; 88:249-260  doi:10.2106/JBJS.E.00215
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Abstract

Background: Orthopaedic surgeons vary in their management of displaced intracapsular fractures of the hip in healthy older patients. The aim of this investigation was to determine the functional, clinical, and resource consequences of three different types of surgical treatment.

Methods: The study was a multicenter randomized controlled trial. Reduction and fixation was compared with bipolar hemiarthroplasty with cement and total hip replacement with cement. Participating surgeons elected to randomize their patients to be treated with either one of the three types of procedures or with either fixation or bipolar hemiarthroplasty. Functional outcomes were measured with a hip-rating questionnaire and the EuroQol health status measure. Clinical outcomes included mortality and complications. The direct health service costs were compared. Participants were followed up for two years.

Results: Two hundred and seven patients were randomized to be treated with one of the three operations, and ninety-one were randomized to be treated with either fixation or bipolar hemiarthroplasty. There were no differences in the mortality rates among the treatment groups. The rate of secondary surgery was highest in the fixation group (39% compared with 5% in the group treated with bipolar hemiarthroplasty and 9% in the group treated with total hip replacement). The fixation group had the worst hip-rating-questionnaire and EuroQol scores at four and twelve months. The total hip replacement group had significantly better functional outcome scores at twenty-four months than the other two groups. Although fixation was initially the least costly procedure, this short-term advantage was eroded by significantly higher costs for subsequent hip-related hospital admissions.

Conclusions: Arthroplasty is more clinically effective and cost-effective than reduction and fixation in healthy older patients with a displaced intracapsular fracture of the hip. The long-term results of total hip replacement may be better than those of bipolar hemiarthroplasty.

Level of Evidence: Therapeutic Level II. See Instructions to Authors for a complete description of levels of evidence.

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    Accreditation Statement
    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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    Andor Sebestyen
    Posted on April 20, 2006
    Different Survival Of Patients With Displaced Femoral Neck Fracture According To Surgical Methods
    County Baranya Health Insurance Fund Administration, 7623 Pécs, Hungary

    To The Editor:

    We read with great interest the paper of Keating and colleagues [1]. The results, especially those of the economic analysis, are of great importance to a health care financing agency like the Hungarian National Health Insurance Fund Administration (OEP), which provides full health insurance coverage for 10.2 million people in a single payer system [2].

    However, such a study raises interesting questions about how the results of a large randomized trial relate to everyday medical practice [3]. In order to analyze the relationship between surgical methods and mortality after femoral neck fracture, we analyzed the survival rates of all patients who sustained a displaced intracapsular femoral neck fracture in 2000. Data were extracted from the nationwide database of the National Health Insurance Fund Administration; we verified our administrative data by a questionnaire completed by the participating hospitals.

    Altogether, 2558 patients from all of Hungary were included in the study (mean age=78.14 ± 8.410). 2124 patients (mean age=78.26 ± 8.501) underwent reduction and fixation and 434 patients (mean age=77.53 ± 7.933) underwent arthroplasty (including hemi and total). One-way analysis of variance (ANOVA) showed no significant difference in the mean age of the patient groups (F=2.724, P=0.099).

    Figure 1(below) shows the Kaplan-Meier survival curves of patients according to surgical methods. Overall survival at 2170 days follow up was 33.97 % with significant differences in mortality according to the type of surgical method: reduction and fixation 32.72; % and arthroplasty 40.09 %. (log rank test 11.53, df=1, p <_0.0007. p="p" /> Although we did not stratifiy the patients according to health status (with or without co-morbidities) or further complications (with or without reoperation), we would like to emphasize that the results coming from even a well-designed randomized trial may differ from similar outcome measures analyzed on a nationwide administrative dataset of unselected patients.


    Fig. 1

    References:

    1. Keating JF, Grant A, Masson M, Scott NW, Forbes JF on behalf of the Scottish Orthopaedic Trials Network. Randomized comparison of reduction and fixation, bipolar hemiarthroplasty, and total hip arthroplasty. Treatment of displaced intracapsular hip fractures in healthy older patients. J Bone Joint Surg Am. 2006; 88:249-260.

    2. Boncz I, Nagy J, Sebestyén A, Kõrösi L (2004) Financing of health care services in Hungary. Eur J Health Econ. 2004; 5(3):252-258.

    3. Fisher CB. Clinical trials results databases: unanswered questions. Science, 2006; 311: 180-181.

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