Extract
Question: In patients having total hip replacement, is celecoxib as
effective as ibuprofen in preventing heterotopic ossification 3 months after
surgery?Design: Randomized (allocation concealed), blinded (outcome
assessors), controlled trial with 3-month follow-up.Setting: A university hospital in Geneva, Switzerland.Patients: 250 patients (mean age, 70 y; 54% women) with severe
osteoarthritis of the hip who were scheduled for total hip replacement.
Exclusion criteria were moderate to severe renal impairment, a history of
gastrointestinal ulcers, and immediate-type hypersensitivity to nonsteroidal
anti-inflammatory drugs (NSAIDs) or cyclooxygenase-2 (COX-2) inhibitors. 240
patients (96%) were available for
follow-up.