JBJS | Bone Grafts and Bone Graft Substitutes in Orthopaedic Trauma Surgery: A Critical Analysis

The Journal of Bone & Joint Surgery, Volume 89, Issue 3

Current Concepts Review | March 01, 2007

Bone Grafts and Bone Graft Substitutes in Orthopaedic Trauma Surgery: A Critical Analysis

William G. De LongJr., MD¹; Thomas A. Einhorn, MD²; Kenneth Koval, MD³; Michael McKee, MD⁴; Wade Smith, MD⁵; Roy Sanders, MD⁶; Tracy Watson, MD⁷

¹ Department of Orthopaedic Surgery, Temple University, One Greentree Centre, Suite 104, Marlton, NJ 08053. E-mail address: william.delong@tuhs.temple.edu
² Department of Orthopaedics, Boston University Medical Center, 720 Harrison Avenue, Suite 808, Boston, MA 02118
³ Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756
⁴ St. Michael's Hospital, 55 Queen Street East, Suite 800, Toronto, ON M5C 1R6, Canada
⁵ Denver Health Medical Center, 777 Bannock Street, Denver, CO 80204
⁶ Florida Orthopaedic Institute, 4 Columbia Drive, Suite 710, Tampa, FL 33606-3568
⁷ Department of Orthopaedic Surgery, St. Louis University Health Science Center, 3635 Vista Avenue, 7th Floor, St. Louis, MO 63110-0250

The Journal of Bone & Joint Surgery. 2007; 89:649-658 doi:10.2106/JBJS.F.00465

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Extract

Osteoinduction is a process that supports the mitogenesis of undifferentiated mesenchymal cells, leading to the formation of osteoprogenitor cells that form new bone. The human skeleton has the ability to regenerate itself as part of the repair process. Recombinant bone morphogenetic protein has osteoinductive properties, the effectiveness of which is supported by Level-I evidence from current literature sources. Osteoconduction is a property of a matrix that supports the attachment of bone-forming cells for subsequent bone formation.

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Topics

bone transplantation ; trauma surgery ; allografting ; tissue scaffolds ; calcium phosphates ; bone marrow ; bone matrix ; fracture ; osteogenesis

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These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.

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