JBJS | Tibial Cartilage Hypertrophy Due to Matrix-Associated Autologous Chondrocyte Transplantation of the Medial Femoral Condyle: A Case Report

The Journal of Bone & Joint Surgery, Volume 91, Issue 8

Case Reports | August 01, 2009

Tibial Cartilage Hypertrophy Due to Matrix-Associated Autologous Chondrocyte Transplantation of the Medial Femoral Condyle: A Case Report

Goetz H. Welsch, MD¹; Siegfried Trattnig, MD¹; Brigitte Tichy²; Tallal C. Mamisch, MD³; Barbara Wondrasch, PT²; Stefan Marlovits, MD²

¹ MR Center-High Field MR, Department of Radiology, Medical University of Vienna, Lazarettgasse 14, A-1090 Vienna, Austria. E-mail address for G.H. Welsch: welsch@bwh.harvard.edu
² Center of Joints and Cartilage, Department of Trauma Surgery (B.T. and S.M.), and Academy for Physiotherapy (B.W.), Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria
³ Department of Orthopaedic Surgery, University of Berne, Freiburgstrasse, 3010 Berne, Switzerland

The Journal of Bone & Joint Surgery. 2009; 91:1996-2001 doi:10.2106/JBJS.H.01180

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Extract

Osteochondral graft hypertrophy is commonly seen after autologous chondrocyte transplantation with use of a periosteal flap^1,2. Reoperation may be performed because of a high grade of hypertrophy causing persistent clinical symptoms. The use of a collagen membrane to cover the chondrocyte suspension can reduce the risk of graft hypertrophy^3,4. Further technological advances have led to a third generation of autologous chondrocyte transplantation with use of biomaterials seeded with chondrocytes as so-called all-in-one scaffolds that generate new articular cartilage⁵. Nevertheless, graft hypertrophy continues to occur, although the prevalence has been reduced with matrix-associated autologous chondrocyte transplantation^6,7.

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Topics

cartilage ; tibia ; femoral medial condyle ; cartilage hypertrophy ; autologous chondrocyte implantation ; range of motion

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These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.

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