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Bilateral Metal-on-Metal Hybrid Hip Resurfacing in a Patient with OsteopetrosisA Case Report
Chen-Ti Wang, MD, PhD1; Harlan C. Amstutz, MD2
1 Department of Orthopedics, National Taiwan University Hospital and National Taiwan University College of Medicine, Number 7, Chung-Shan South Road, Taipei, Taiwan
2 Joint Replacement Institute, The S. Mark Taper Building, 2200 West Third Street, Suite 400, Los Angeles, CA 90057. E-mail address: harlanamstutz@dochs.org
The Journal of Bone & Joint Surgery.  2009; 91:2941-2944  doi:10.2106/JBJS.H.01430
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Extract

Osteopetrosis, also known as marble bone disease1, is a rare inherited skeletal condition characterized by failure of osteoclast-mediated bone resorption. Orthopaedic surgeons most commonly encounter patients with the benign autosomal-dominant type of adult-onset osteopetrosis, who often first learn of their diagnosis after sustaining a fracture. The lifelong prevalence of fractures in this patient group ranges from 40% to 66.6%2-5. Other clinical manifestations include coxa vara (caused by stress-induced microfractures in the femoral neck), spine problems (scoliosis, spondylolysis, cervical spine fractures, and idiopathic low back pain), osteomyelitis, and cranial nerve compression syndromes.
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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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