Extract
Improved understanding and management of the risk factors associated with osteoarthritis of the knee are clearly desirable, especially considering the shifts in the age distribution of the US population toward older ages. Among the various genetic, constitutional, and biomechanical insults that are believed to cause metabolic and structural changes in the synovial joint, two of the recognized local adverse biomechanical factors are rupture of the anterior cruciate ligament and malalignment of the lower limb.